Philadelphia University + Thomas Jefferson University

Iwamoto, Masahiro

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Masahiro Iwamoto, DDS, PhD

Contact Dr. Iwamoto

1015 Walnut Street
Curtis Building, Room 501
Philadelphia, PA 19107

(215) 955-4076
(215) 955-9159 fax

Medical School

DDS, Tokushima University, School of Dental Medicine - 1984
PhD, Osaka University, Graduate School of Dentistry - 1988

Expertise and Research Interests

During embryogenesis, chondrocytes at the epiphyseal tip of long bone models give rise to articular tissue and persist through life, whereas chondrocytes in the shaft undergo hypertrophy, mineralization and apoptosis and are replaced by bone cells. It is not understood how chondrocytes undertake these alternative pathways and fates. We have been reported that C-1-1, a novel isoform of chick ets-related gene (ERG) is preferentially expressed in articular cartilage and its expression is down-regulated during maturation of chondrocytes. Over-expression of C-1-1 not only inhibits maturation of chondrocytes but also converts type X collagen positive trangient chondrocytes to tenascin-C positive permanent articular chondrocytes like cells. In developing mouse skeleton, ERG is highly expressed in future joint region and surface zone of articular cartilage. Those findings suggest that ERG plays an important role in permanent articular cartilage formation. We are studying mechanism of action, regulation of expression, interaction and interplay with other signaling factors, and the effect of down-regulation of ERG in chondrocytes.

Languages

English
Japanese

Publications

Most Recent Peer-Reviewed Publications

  1. Synergistic role of endothelial erg and fli1 in mediating pulmonary vascular homeostasis
  2. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development
  3. Extracellular vesicles released from mesenchymal stromal cells stimulate bone growth in osteogenesis imperfecta
  4. Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat-related heterotopic ossification
  5. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  6. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation
  7. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
  8. Alpha 5 integrin mediates osteoarthritic changes in mouse knee joints
  9. Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model
  10. The role of sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction
  11. Wnt signaling in cartilage development and diseases: Lessons from animal studies
  12. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg
  13. Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells
  14. Endothelial erg expression is required for embryogenesis and vascular integrity
  15. Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse
  16. Resident mesenchymal progenitors of articular cartilage
  17. The pathophysiology of heterotopic ossification: Current treatment considerations in dentistry
  18. Distribution of slow-cycling cells in epiphyseal cartilage and requirement of β-catenin signaling for their maintenance in growth plate
  19. Sonic Hedgehog Regulates Osteoblast Function by Focal Adhesion Kinase Signaling in the Process of Fracture Healing
  20. Toward regeneration of articular cartilage