Philadelphia University + Thomas Jefferson University

Sykulev, Yuri

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Yuri K. Sykulev, MD, PhD

Contact Dr. Sykulev

233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107

(215) 503-4530
(215) 923-4153 fax

Research and Clinical Interests

The major goal of my research program is to understand molecular mechanisms  regulating various activities of cytotoxic lymphocytes. Understanding of these mechanisms, particularly those that lead to the lymphocyte activation and inactivation, is expected to facilitate the development of novel approaches to manipulate lymphocytes receptor-mediated signaling and their responsiveness and would lead to the development of novel immunotherapeutic interventions to treat viral infections, cancer and other diseases.


Most Recent Peer-Reviewed Publications

  1. Evaluating frequency and quality of pathogen-specific T cells
  2. Integrins influence the size and dynamics of signaling microclusters in a Pyk2-dependent manner
  3. Herman N. Eisen: Mentor to many
  4. Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents
  5. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity
  6. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
  7. Enteric alpha defensins in norm and pathology.
  8. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
  9. Enteric alpha defensins in norm and pathology
  10. Role of the MTOC in T cell effector functions
  11. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
  12. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
  13. T cell receptor signaling kinetics takes the stage
  14. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
  15. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
  16. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
  17. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
  18. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
  19. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
  20. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells