Philadelphia University + Thomas Jefferson University

Yang, Hushan

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Hushan Yang, PhD

Hushan Yang, PhD

Contact Dr. Yang

834 Chestnut Street
The Franklin Building, Suite 314
Philadelphia, PA 19107

(215) 503-6521
(215) 503-9506 fax

Research & Clinical Interests

Our research integrates the increasing knowledge of biological mechanisms of cancer development with current interdisciplinary strategies to develop reliable cancer risk and prognosis prediction models. Our study utilizes genetic variation in the human genome and other biological and pathological markers as surrogates of cancer risk and treatment outcome, in order to achieve tailored prediction based on the specific profile of individual patients.

Publications

Most Recent Peer-Reviewed Publications

  1. Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations
  2. Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer
  3. Prognostic values of cancer associated macrophage-like cells (CAML) enumeration in metastatic breast cancer
  4. Genetic variations of mitochondrial genome modify risk and prognosis of hepatocellular carcinoma patients
  5. Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework
  6. Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients
  7. Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer
  8. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis
  9. Detection and characterization of circulating tumor associated cells in metastatic breast cancer
  10. Alterations of telomere length and mtDNA copy number are associated with overall survival in hepatocellular carcinoma patients treated with transarterial chemoembolization
  11. Prospective changes in global DNA methylation and cancer incidence and mortality
  12. Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival from Colon Cancer: A United States Population-Based Study
  13. Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection
  14. Intraoperative ultrasonography for the identification of thoracic recurrent laryngeal nerve lymph nodes in patients with esophageal cancer
  15. The doylestown algorithm: A test to improve the performance of afp in the detection of hepatocellular carcinoma
  16. Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer
  17. The effects of erythropoiesis-stimulating agents on the short-term and long-term survivals in metastatic breast cancer patients receiving chemotherapy: a SEER population-based study
  18. Network-based stratification analysis of 13 major cancer types using mutations in panels of cancer genes
  19. Circulating Mitochondrial DNA Content Associated with the Risk of Liver Cirrhosis: A Nested Case–Control Study
  20. Polymorphisms in genes of tricarboxylic acid cycle key enzymes are associated with early recurrence of hepatocellular carcinoma