Philadelphia University + Thomas Jefferson University

Zhang, Hui

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Hui Zhang, PhD

Contact Dr. Zhang

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 503-7213
(215) 503-4358 fax

Expertise and Research Interests

Research in my laboratory aims to elucidate the pathogenic mechanisms of Parkinson's disease and Schizophrenia at the molecular, cellular and synaptic levels. Much effort is directed at the striatum, the input nucleus of the basal ganglia and the prefrontal cortex, a cortical region which plays a central role in cognition. We employ a combination of electrochemical, electrophysiological, optical imaging, optogenetics, and genetic approaches to explore the plasticity of dopamine neurotransmission, the role of dopamine in modulating information flow and how the process is disturbed in these disorders. In addition, we are developing optical tools to study whether dopamine dys-regulation in schizophrenia is in part due to intrinsic changes in the presynaptic dopamine terminals.

Current Projects

  • The pathophysiology of Parkinson's disease: LRRK2 mediated pathogenic pathways in dopaminergic axonal degeneration and synaptic transmission
  • Dopamine neurotransmission and modulation of the prefrontal cortex in mouse models of schizophrenia
  • The role of tonic and phasic dopamine signaling in the striatum

Publications

Most Recent Peer-Reviewed Publications

  1. Loss of VGLUT3 produces circadian-dependent hyperdopaminergia and ameliorates motor dysfunction and l-dopa-mediated dyskinesias in a model of parkinson’s disease
  2. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain
  3. Vesicular Glutamate Transport Promotes Dopamine Storage and Glutamate Corelease In Vivo
  4. Dopamine release at individual presynaptic terminals visualized with FFNs.
  5. Dopamine release at individual presynaptic terminals visualized with FFNs
  6. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals
  7. Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration
  8. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
  9. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons
  10. Frequency-dependent modulation of dopamine release by nicotine
  11. Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
  12. Erratum: Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing (Journal of Neurochemistry (2003) 87 (1284-1295))
  13. Regulation of the Development of Mesencephalic Dopaminergic Systems by the Selective Expression of Glial Cell Line-Derived Neurotrophic Factor in Their Targets
  14. Dopamine Neurons Mediate a Fast Excitatory Signal via Their Glutamatergic Synapses
  15. Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing
  16. Glutamate Spillover in the Striatum Depresses Dopaminergic Transmission by Activating Group I Metabotropic Glutamate Receptors
  17. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
  18. Contribution of the β subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor
  19. Identification of acetylcholine receptor channel-lining residues in the M1 segment of the β-subunit
  20. Lectin and ion channel