Jeannie Chin, PhD

Contact Dr. Chin

900 Walnut Street
Philadelphia, PA 19107

(215) 503-4294
(215) 955-4949 fax

Research and Clinical Interests

The focus of my research is to understand the cellular and network mechanisms underlying cognitive impairments in Alzheimer's disease (AD), and to identify therapeutic entry points for the treatment of this devastating disease. The amyloid precursor protein (APP) and the amyloid-β (Aβ) peptides derived from it play a central role in AD, although the precise mechanisms by which they impair neuronal function and lead to cognitive deficits remain to be fully defined. Transgenic mouse models of AD produce high levels of Aβ and develop neuropathology and memory deficits similar to those observed in patients with AD, and are thus extremely useful for interrogating the role of Aβ in memory impairments.