Gino Cingolani, PhD
BLSB Room 826
Philadelphia, PA 19107
(215) 923-2117 fax
Most Recent Peer-reviewed Publications
- Dimeric quaternary structure of human laforin
- Diversification of importin-α isoforms in cellular trafficking and
- Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin α Isoforms 3 and 7
- Structure of human PIR1, an atypical dual-specificity phosphatase
- Jamming up the "β-staple": Regulation of SIRT1 activity by its C-terminal regulatory segment (CTR)
Research and Clinical Interests
Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases.
My laboratory uses X-ray crystallography, combined with biophysical and biochemical techniques to probe the structure and function of large macromolecular machines. We are interested in a variety of biological problems, which include the mechanisms and regulation of nucleocytoplasmic transport, the delivery of viral DNA into living cells, and the structure and regulation of multi-subunit ATP synthases. Our structural approach provides a unique tool to understand the function and engineer the activity of biological molecules. Visit our website (http://www.cingolanilab.org/) for more info.