Gino Cingolani, PhD
BLSB Room 826
Philadelphia, PA 19107
(215) 923-2117 fax
Most Recent Peer-reviewed Publications
- Structure of human PIR1, an atypical dual-specificity phosphatase
- Jamming up the "β-staple": Regulation of SIRT1 activity by its C-terminal regulatory segment (CTR)
- Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography
- Coordination of the filament stabilizing versus destabilizing activities of cofilin through its secondary binding site on actin
- The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain
Research and Clinical Interests
Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases.
My laboratory uses X-ray crystallography, combined with biophysical and biochemical techniques to probe the structure and function of large macromolecular machines. We are interested in a variety of biological problems, which include the mechanisms and regulation of nucleocytoplasmic transport, the delivery of viral DNA into living cells, and the structure and regulation of multi-subunit ATP synthases. Our structural approach provides a unique tool to understand the function and engineer the activity of biological molecules. Visit our website (http://www.cingolanilab.org/) for more info.