05B4 Mazo, Alexander M. - Thomas Jefferson University - Thomas Jefferson University
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Alexander M. Mazo, PhD

Contact Dr. Mazo

1020 Locust Street
JAH, Rm. 485
Philadelphia, PA 19107

(215) 503-4785
(215) 923-7144 fax

Most Recent Peer-reviewed Publications

  1. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication.
  2. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
  3. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
  4. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
  5. The Role of Epigenetic Modifications in Cancer
  6. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation
  7. Regulatory noncoding RNAs at Hox loci
  8. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
  9. Transcriptional interference: An unexpected layer of complexity in gene regulation
  10. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
  11. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos
  12. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
  13. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes
  14. ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
  15. Purification and Biochemical Properties of the Drosophila TAC1 Complex
  16. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex
  17. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
  18. Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
  19. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
  20. Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene
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