Ulrich Rodeck, MD
Philadelphia, PA 19107
Most Recent Peer-reviewed Publications
- Immunotargeting and eradication of orthotopic melanoma using a chemokine-enhanced DNA vaccine
- Skinflammation and drug toxicity-A delicate balance
- Skin toxicity of targeted cancer agents: Mechanisms and intervention
- Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells
- Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
Research and Clinical Interests
Regulation of epithelial cell fate by the epidermal growth factor receptor and associated signal transduction events; molecular mechanisms leading to adverse events of cancer therapy; adverse event reduction by developing drugs targeted to disease sites; zebrafish as an in vivo model system to investigate whole organism genotoxic stress responses.
My research interests revolve around signal transduction pathways regulating epithelial cell death and survival. Specifically, I am interested in coordinated signaling by receptor tyrosine kinases and integrins as it relates to the inappropriate survival of tumor cells. In these studies, we frequently use an EGFR antagonistic monoclonal antibody originally developed at the Wistar Institute (Rodeck et al. Cancer Res., 47:3692-6, 1987) and currently in phase II clinical trials in epithelial neoplasms (EMD59000; EMD72000). A second line of investigation focuses on molecular determinants of stress response pathways in vertebrate organisms. This work is done largely in zebrafish embryos to account or microenvironmental and tissue-specific effects. The goal of these studies is to identify targets for therapeutic intervention in cancer and inflammatory diseases.