Michael R. Sperling, MD
Philadelphia, PA 19107
(215) 503-2481 fax
Most Recent Peer-reviewed Publications
- Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy
- Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: A randomized historical-control phase III study based in North America
- Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial
- Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy
- Resting-state functional connectivity predicts the strength of hemispheric lateralization for language processing in temporal lobe epilepsy and normals
Research and Clinical Interests
Clinical epilepsy, EEG
The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.
The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.