Yuri K. Sykulev, MD, PhD
Bluemle Life Sciences Building 706
Philadelphia, PA 19107
(215) 923-4153 fax
Most Recent Peer-reviewed Publications
- Integrins influence the size and dynamics of signaling microclusters in a Pyk2-dependent manner
- Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity
- Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents
- Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
- Enteric alpha defensins in norm and pathology.
Research and Clinical Interests
The major goal of my research program is to understand molecular mechanisms regulating various activities of cytotoxic lymphocytes. Understanding of these mechanisms, particularly those that lead to the lymphocyte activation and inactivation, is expected to facilitate the development of novel approaches to manipulate lymphocytes receptor-mediated signaling and their responsiveness and would lead to the development of novel immunotherapeutic interventions to treat viral infections, cancer and other diseases.