16D0 Trotti, David - Thomas Jefferson University - Thomas Jefferson University
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Davide Trotti, PhD

Contact Dr. Trotti

900 Walnut Street
Suite 451
Philadelphia, PA 19107

(215) 955-8416
(215) 503-9128 fax

Most Recent Peer-reviewed Publications

  1. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
  2. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization
  3. Sumoylation of critical proteins in amyotrophic lateral sclerosis: Emerging pathways of pathogenesis
  4. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS
  5. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
  6. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
  7. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
  8. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria
  9. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
  10. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis
  11. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
  12. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis
  13. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
  14. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
  15. Modulation of DMT1 Activity by Redox Compounds
  16. A role for glutamate transporters in neurodegenerative diseases
  17. Neutral amino acid absorption in the midgut of lepidopteran larvae
  18. Regulation of glutamate transporters in health and disease
  19. Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
  20. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
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