Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Student Publications

Student Publications 2010

Biochemistry & Molecular Biology
Shankar H., Michal A., Kern R.C., Kang D.S., Gurevich V.V., and Benovic J.L 2010. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J Biol Chem. 285:8316-29.

Cell & Developmental Biology
Yan, Y; Zhang, GX; Gran, B; Fallarino, F; Yu, S; Li, H; Cullimore, M; Rostami, A; Xu, H. IDO upregulates Treg cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in EAE. J Immunol. Submitted.

Gawron, K., Jensen, D.A., Steplewski, A., and A. Fertala 2010. Reducing the effects of intracellular accumulation of thermolabile collagen II mutants by increasing their thermostability in cell culture conditions. Biochem Biophys Res Commun 396(2):213-8.

Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J. 2010. Glycogen synthase kinase-3beta regulates post myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circulation Research. 106(10): 1635-45.

Genetics
Abel EV and AE Aplin. 2010. FOXD3 Is a Mutant B-RAF–Regulated Inhibitor of G1-S Progression in Melanoma Cells. Cancer Research 70:2891-2900.

Abel EV and AE Aplin. 2010. Finding the root of the problem: the quest to identify melanoma stem cells. Frontiers in Bioscience (in press).

Dean JL, Thangavel C, McClendon AK, Reed CA and ES Knudsen. 2010. Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure. Oncogene. Jul 15;29(28):4018-32. Epub 2010 May 17.

McClendon AK, Dean JL, Ertel A and ES Knudsen. 2010. Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model. PLoS One Jan 1;5(1):e8558.

Dean JL, McClendon AK, Stengel KR and ES Knudsen. 2010. Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context. Oncogene Jan 7;29(1):68-80. Epub 2009 Oct 5.

Book Chapter: Cell Cycle Deregulation in Cancer. Chapter 3. Greg Enders, Editor. Springer; 1st Edition (March 22, 2010). (Student Author: Dean JL)

Hu R and AE Aplin. 2010. αB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells. Pigment Cell Melanoma Research 23: 201-209.

Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, Meng R, Quong AA, Latz E, Scott CP and ES Alnemri. 2010. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. Journal of Biological Chemistry Mar 26;285(13):9792-9802.

Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP and ES Alnemri. 2010. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nature Immunology. May;11(5):385-393.

Orr CR, Liu Y, Bolzoni E, Monti HL, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP and DE Merry. 2010. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy (submitted).

Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F and MP Lisanti. 2010. Transcriptional Evidence for the “Reverse Warburg Effect” in Human Breast Cancer Stroma: Similarities with Alzheimer’s Disease Brain. Aging April:2 (4):185-199.

Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F and MP Lisanti. 2010. The Reverse Warburg Effect: Glycolysis Inhibitors Prevent the Tumor Promoting Effects of Caveolin-1 Deficient Cancer Associated Fibroblasts. Cell Cycle May:9 (10):1960-1971.

Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F and MP Lisanti. 2010. Loss of Stromal Caveolin-1 Leads to Oxidative Stress, Mimics Hypoxia, and Drives Inflammation in the Tumor Microenvironment, Conferring the Reverse Warburg Effect. A Transcriptional Informatics Analysis with Validation. Cell Cycle June:9 (11):2201-2219.

Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Flomenberg N, Tsirigos A, Martinez-Outschoorn UE, Howell A, Sotgia F and MP Lisanti. 2010. Glycolytic Cancer Associated Fibroblasts Promote Breast Cancer Tumor Growth, without a Measurable Increase in Angiogenesis: Evidence for Stromal-Epithelial Metabolic Coupling. Cell Cycle June:9 (12):2412-2422.

Martinez-Outschoorn UE, Pavlides S, Whitaker-Menezes D, Daumer KM, Milliman JN, Chiavarina B, Migneco G, Witkiewicz AK, Martinez-Cantarin MP, Flomenberg N, Howell A, Pestell RG, Lisanti MP and F Sotgia. 2010. Tumor Cells Induce the Cancer Associated Fibroblast Phenotype Via Caveolin-1 Degradation: Implications for Breast Cancer and DCIS Therapy with Chloroquine. Cell Cycle June:9 (12):2423-2433.

Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C and RG Pestell. 2010. The Dachshund Gene in Development and Hormone-Responsive Tumorigenesis. Trends in Endocrinology and Metabolism 21(1):41-49.

Olshavsky NA, Comstock CE, Schwiewer MJ, Augello MA, Hyslop T, Sette C, Zhang J, Parysek LM and KE Knudsen. 2010. Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. Cancer Research May 15;70 (10):3975-3984.

Immunology & Microbial Pathogenesis
Coffey F, Manser T. (2010). Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010 May 1;184(9):4871-9.

Colombo M. J., Sun G., Alugupalli K. R. 2010. T cell-independent immune responses do not require Cxcl13-mediated B1 cell migration. Infection and Immunity. 78(9):3950-6.

Dickinson G. S., Piccone H., Sun G., Lien E., Gatto L., Alugupalli K. R. 2010. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infection and Immunity. Aug 9. [Epub ahead of print].

Faul EJ, Wanjalla CN, Suthar MS, Gale M, Wirblich C, Schnell MJ. (2010). Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLoS Pathog. 2010 Jul 22;6(7):e1001016.

Gomme, E.A., Faul, E.J., Flomenberg, P., McGettigan, J.P., and Schnell, M.J. (2010) Characterization of a single-cycle rabies virus-based vaccine vector. J Virol. 84(6): 2820-31.

Xu RH, Remakus S, Ma X, Roscoe F, Sigal LJ. Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response. PLoS Pathogens. 2010 Feb 12;6(2):e1000768.

Magee MS, Snook AE, Siciliano, NA, Waldman, SA. 2010. Barriers to, and prospective solutions for, colorectal cancer immunotherapy. Immunogenicity, in press.

Apcher, G.S., Testa, J.S., Robinson, T., and Eisenlohr, L.C. (2010). Manuscript in preparation.

Testa, J.S., Apcher, G.S., and Eisenlohr, L.C. (2010). “Exosome-driven MHCII antigen transfer facilitated by the receptor binding activity of influenza hemagglutinin.” The Journal of Immunology Manuscript under review.

Gomathinayagam, S., Testa J.S., Tewari M.K., Cresswell P., Maric M., and Eisenlohr L.C. (2010). “Influenza and poxvirus immunity in interferon-g inducible lysosomal thiol reductase (GILT)-free mice.” The Journal of Immunology Manuscript under review.

Testa, J.S. and Eisenlohr, L.C. (2010). “Using a well-established system for targeted antigen delivery, the authors demonstrate the importance of antigen uptake and delivery to a specific endosomal compartment for cross-presentation.” Faculty of 1000 Biology evaluation, http://f1000biology.com/article/id/1387978/evaluation. Article featured as third in the “Top 10 Most Viewed” on f1000.

Faul EJ, Wanjalla CN, Suthar MS, Gale M, Wirblich C, Schnell MJ. Rabies Virus Infection Induces Type I Interferon Production in an IPS-1 Dependent Manner While Dendritic Cell Activation Relies on IFNAR Signaling. PLoS Pathog. 2010 Jul 22;6(7):e1001016.

Mareeva T, Wanjalla C, Schnell MJ, Sykulev Y. A novel composite immunotoxin that suppresses rabies virus production by the infected cells. J Immunol Methods. 2010 Feb 28;353(1-2):78-86.

Molecular Pharmacology & Structural Biology

Olshavsky NA, Comstock CE, Schiewer MJ, Augello MA, Hyslop T, Sette C, Zhang J, Parysek LM, Knudsen KE, Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene, Cancer Res., 2010, 70:3975-84.

Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA, The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling, Gastroenterology. 2010, 138:241-54.

Völkers M, Rohde D, Goodman C, Most P. 2010. S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function. J Biomed Biotchnol 2010:178614 (epub 2010 Mar 28).

Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA, The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling, Gastroenterology. 2010, 138:241-54.

Valentino MA, Lin JE, Waldman SA, Central and peripheral molecular targets for antiobesity pharmacotherapy, Clin Pharmacol Ther. 2010, 87(6):652-62.

Sun S, Siglin A, Williams JC, Polenova T, Solid-state and solution NMR studies of the CAP-Gly domain of mammalian dynactin and its interaction with microtubules, J Am Chem Soc. 2009. 131(29):10113-26.

Ahmed S, Sun S, Siglin AE, Polenova T, Williams JC, Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain, Biochemistry. 2010, 49(25):5083-5.

Valentino MA, Lin JE, Waldman SA, Central and peripheral molecular targets for antiobesity pharmacotherapy, Clin Pharmacol Ther. 2010, 87(6):652-62.

Neuroscience
Dearworth JR Jr, Sipe GO, Cooper LJ, Brune EE, Boyd AL, Riegel RA 2010. Consensual pupillary light response in the red-eared slider turtle (Trachemys scripta elegans). Vision Research. 50:598-605.

Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P. 2010. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. Human Molecular Genetics. 19(15): 2974–2986.

Scavone, J.L., Mackie, K., and Van Bockstaele, E.J. 2010. Characterization of cannabinoid-1 receptors in the locus coeruleus: relationship with mu-opioid receptors. Brain Research 1312:18-31.

Scavone, J.L. Sterling, R.C., Weinstein, S.P., and Van Bockstaele, E.J. 2010. Impact of Cannabis Use During Stabilization on Methadone Maintenance Treatment. Submitted

MS in Biomedical Sciences:
Levi L, Pekarski I, Gutman E, Fortina P, Hyslop T, Biran J, Levavi-Sivan B, Lubzens E. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. BMC Genomics. 2009 Mar 31;10:14

Silvers RM, Smith JA, Schowalter M, Litwin S, Liang Z, Geary K, Daniel R. Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein. Hum Gene Ther. 2010 Mar;21(3):337-49.

Student Publications in 2009
Molecular Pharmacology & Structural Biology
Comstock CE, Augello MA, Benito RP, Karch J, Tran TH, Utama FE, Tindall EA, Wang Y, Burd CJ, Groh EM, Hoang HN, Giles GG, Severi G, Hayes VM, Henderson BE, Le Marchand L, Kolonel LN, Haiman CA, Baffa R, Gomella LG, Knudsen ES, Rui H, Henshall SM, Sutherland RL, Knudsen KE, Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer, Clin Cancer Res., 2009, 15:5338-49

Buchsbaum, MS, Hazendar M, Newmark RE, Chu KW, Dusi N, Entis JJ, Goldstein KE, Goodman CR, Gupta A, Hazlett E, Iannuzzi J, Torosyan Y, Zhang J, Wolin A. 2009. FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia. Schizophrenia Research 114(1-3):161-71.

Kahle KM
, Steger HK, Root MJ, Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding, PLoS Pathog. 2009, 5(11):e1000674

Li P, Lin JE, Marszlowicz GP, Valentino MA, Chang C, Schulz S, Pitari GM, Waldman SA, GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?, Drug News Perspect. 2009, 22(6):313-8.

Li P, Lin JE, Marszlowicz GP, Valentino MA, Chang C, Schulz S, Pitari GM, Waldman SA, GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?, Drug News Perspect. 2009, 22(6):313-8.

Li P, Lin JE, Schulz S, Pitari GM, Waldman SA, Can colorectal cancer be prevented or treated by oral hormone replacement therapy?, Curr Mol Pharmacol. 2009, 2(3):285-92.

Gong L, Debruyne PR, Witek M, Nielsen K, Snook A, Lin JE, Bombonati A, Palazzo J, Schulz S, Waldman SA, Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis, Clin Transl Sci. 2009, 2(4):286-93.

Genetics
Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW and ES Knudsen. 2009. SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell July;20(14):3192-3199.

Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ and T Otevrel. 2009. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Molecular Carcinogenesis Sep;48(9):821-831.

Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B and AD Eckhart. 2009. G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. Hypertension. 54(1):71-76.

Mercier I, Jasmin J-F, Pavlides S, Minetti C, Pestell RG, Frank PG, Sotgia F and MP Lisanti. 2009. Clinical and Translational Implications of the Caveolin Gene Family: Lessons from Mouse Models and Human Genetic Disorders. Lab Invest 89:614-623.

Frank PG, Pavlides S and MP Lisanti. 2009. Caveolae and Transcytosis in Endothelial Cells: Role in Atherosclerosis. Cell Tissue Research 335: 41-47.

Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F and MP Lisanti. 2009. The Reverse Warburg Effect: Aerobic Glycolysis in Cancer Associated Fibroblasts and the Tumor Stroma. Cell Cycle 8: (23) 3984-4001.

Shuda K, Schindler K, Ma J, Schultz RM and PJ Donovan. 2009. Aurora kinase B modulates chromosome alignment in mouse oocytes. Mol Reproduction & Development 76(11):1094-1105.

Tissue Engineering and Regenerative Medicine
Tran, CM, Markova, D, Smith, HE, Susarla, B, Ponnappan, RK, Anderson, DG, Symes, A, Shapiro, IM, Risbud, MV 2010 Regulation of CCN2/CTGF expression in the nucleus pulposus of the intervertebral disc: Role of smad and AP1 signaling. Arthritis Rheum. 62, 1983-92 2010

MS in Biomedical Sciences
Williams JH, Schray RC, Patterson CA, Ayitey SO, Tallent MK, Lutz GJ. Oligonucleotide-mediated survival of motor neuron protein expression in CNS improves phenotype in a mouse model of spinal muscular atrophy. J Neurosci. 2009 Jun 17;29(24):7633-8

Sirsi SR, Schray RC, Wheatley MA, Lutz GJ. Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides. J Nanobiotechnology. 2009 Apr 7;7:1.

Student Publications in 2007
Busillo, J. M., and Benovic, J. L. (2007). Regulation of CXCR4 Signaling. Biochim Biophys Acta 1768, 952-963.

Chen, X. L., Silver, H. R., Xiong, L., Belichenko, I., Adegite, C., and Johnson, E. S. (2007). Topoisomerase I-dependent viability loss in Saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair. Genetics.

Chen, Y., Perussia, B., and Campbell, K. S. (2007). PGD2 Suppresses Human NK Cell Function Via Signaling Through D Prostanoid (DP) Receptor1. J Immunol in press.

Fu, M., Liu, M., Sauve, A. A., Jiao, X., Zhang, X., Wu, X., Powell, M. J., Yang, T., Gu, W., Avantaggiati, M. L., et al. (2006). Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol 26, 8122-8135.

Li, Z., Wang, C., Jiao, X., Katiyar, S., Powell, M. J., and Pestell, R. G. (2007). The cyclin D1a and cyclin D1b splice variants: Differential cellular migratory properties through elevation of p27Kip1 binding. Cancer Research In press.

Snook, A. E., Stafford, B. J., Eisenlohr, L. C., Rothstein, J. L., and Waldman, S. A. (2007). Mucosally restricted antigens as novel immunological targets for antitumor therapy. Biomarkers in Medicine 1, 187-202.

Powell, M. J., Li, S., Lisanti, M., Nevalainen, M., Wang, C., and Pestell, R. G. (2007). Epigenetic Modification and Acetylation of the Androgen Receptor Regulates Prostate Cellular Growth., Vol In print.

Powell, M. J., Popov, V. M., and Pestell, R. G. (2007). Nuclear Receptors and Cyclins in Hormone Signaling.

Roy, A., and Hooper, D. C. (2007). Lethal Silver-Haired Bat Rabies Virus Infection Can Be Prevented by Opening The Blood-Brain Barrier. J Virol 81, 7993-7998.

Roy, A., Phares, T. W., Koprowski, H., and Hooper, D. C. (2007). Failure to open the blood-brain barrier and deliver immune effectors to the CNS tissues leads to the lethal outcome of Silver-haired bat rabies virus infection. J Virol 81, 1110-1118.

Whittle, J. R., Powell, M. J., Popov, V. M., Shirley, L. A., Wang, C., and Pestell, R. G. (2007). Nuclear Receptor Acetylation and the Function of Sirtuins in Endocrinology and Metabolism. Trends in Endocrinology and Metabolism in press.

Student Publications in 2006
Ambrose, L. M., Gallagher, S. M., Unterwald, E. M., and Van Bockstaele, E. J. (2006). Dopamin-D1 and d-opioid receptors co-exist in rat striatal neurons. Neuroscience Letters 399, 191-196.

Student Publications in 2005
Perussia, B., Chen, Y., and Loza, M. J. (2005). Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell. Mol Immunol 42, 385-395.

Student Publications in 2004
Ambrose, L. M., Unterwald, E. M., and Van Bockstaele, E. J. (2004). Ultrastructural evidence for co-localization of dopamine D2 and µ-opioid receptors in the rat dorsolateral striatum. Anatomical Record 279A, 583-591.

Student Publications in 2003
Prosniak, M., Zborek, A., Scott, G. S., Roy, A., Phares, T. W., Koprowski, H., and Hooper, D. C. (2003). Differential expression of growth factors at the cellular level in virus-infected brain. Proc Natl Acad Sci U S A 100, 6765-6770.

Roy, A., and Wonderlin, W. F. (2003). The permeability of the endoplasmic reticulum is dynamically coupled to protein synthesis. J Biol Chem 278, 4397-4403.