Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Faculty

esa101

Emad Alnemri, PhD
Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular mechanisms of programmed cell death (apoptosis); Pattern recognition receptors and inflammasome activation in innate immune responses to molecular danger signals; role of mitochondria in survival, cell death and aging.


aea004

Andrew E. Aplin, PhD
Professor, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Targeting mutant BRAF and integrin signaling in melanoma.


jlb104

Jeffrey L. Benovic, PhD
Professor and Chair, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Molecular and regulatory properties of G protein-coupled receptors; role of receptor dysregulation in cancer and neurological disorders.


jrb006

Jonathan R. Brody, PhD
Associate Professor, Surgery
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Novel therapeutic strategies for pancreatic cancer patients; primarily focused on HuR biology as it relates to the clinical management of cancer, including identifying clinically relevant HuR targets.


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Bruno Calabretta, MD, PhD
Professor, Cancer Biology
Molecular Biology and Gene Regulation

Molecular mechanisms of normal hematopoiesis and BCR/ABL-dependent leukemogenesis.


gxc012

Gino Cingolani, PhD
Associate Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases.


mlc105

Manuel Covarrubias, MD, PhD
Professor, Neuroscience
Chemical and Structural Biology

Voltage-gated ion channels; Structure, Function, Regulation and Mechanisms


mxd073

Matthew Dalva, PhD
Associate Professor, Neuroscience
Molecular and Cellular Pharmacology

The long-range goal of my research program is to understand how synapses and functional neural circuits are generated.


axd121

Adam P. Dicker, MD, PhD
Professor and Chair, Radiation Oncology
Molecular and Cellular Pharmacology

Molecular pharmacology and therapeutics; testing novel anti-cancer agents both pre-clinically and clinically with ionizing radiation and current systemic therapies.


Masumi Eto, PhD

Masumi Eto, PhD
Associate Professor, Molecular Physiology & Biophysics
Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Signal transduction in controlling cytoskeletons and protein phosphatases.


jlf101

John L. Farber, MD
Professor, Pathology, Anatomy & Cell Biology
Molecular and Cellular Pharmacology

Biochemical mechanisms of cell injury in ischemia; biochemical toxicology of liver cell necrosis; biochemical toxicology of activated oxygen; chemical carcinogenesis.


fxf105

Flemming Forsberg, MD
Professor, Radiology
Chemical and Structural Biology, Molecular & Cellular Pharmacology,
Molecular Biology & Gene Regulation

Contrast enhanced ultrasound imaging, in particular subharmonic imaging and subharmonic aided pressure estimation, as well as ultrasound image processing and Elastography.


mef005

Mark Fortini, PhD
Associate Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Developmental signaling pathways involved in normal cellular patterning and cancer; proteolytic mechanisms in neurogenesis and neurodegeneration; trafficking and post-translational regulation of cell-surface receptors and ligands.


njh102

Noreen J. Hickok, PhD
Associate Professor, Orthopaedic Surgery
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Development of surfaces for combating implant-associated infection; bacterial-osteoblastic cell interactions; role of extracellular bone matrix in bone formation, bacterial adhesion, and latent infections.


jxh138

Jan B Hoek, PhD
Professor, Pathology, Anatomy & Cell Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.


mah010

Michael Holinstat, PhD
Associate Professor, Medicine, Division of Hematology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Regulation of protease-activated receptor (PAR) function in the platelet; signal transduction and regulation of hemostasis and thrombosis in the platelet; Regulation of the small GTPase Rap1 in vascular function; regulation of platelet-mediated hemostasis and thrombosis and signal transduction by 12-Lipoxygenase; 12-Lipoxygenase as a novel approach to anti-platelet therapy; study how platelet function regulates the progression of a number of cardiovascular risks such as diabetes and acute coronary syndrome


yxh103

Ya-ming Hou, PhD
Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular & Cellular Pharmacology,
Molecular Biology & Gene Regulation

Genetic and biochemical studies of tRNA, including structure and function mechanism of tRNA aminoacylation, maintenance of the tRNA 3' end, maturation and processing, editing and repair, decoding on the ribosome, and development of bacterial pathogenesis in infectious diseases; targeting tRNAs as strategies against metabolic and neurodegenerative disorders.


jbj101

James B. Jaynes, PhD
Professor, Biochemistry & Molecular Biology
Molecular Biology and Gene Regulation

Developmental genetics and molecular biology of gene regulation by epigenetic transcriptional memory and chromosomal architecture.


hxk113

Hideko Kaji, PhD
Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular mechanisms/function of A) prokaryotic and eukaryotic ribosome recycling in protein synthesis B) protein modification by arginylation via arginyl tRNA protein transferase.


cbk002

Caleb B. Kallen, MD, PhD
Associate Professor,Department of Obstetrics & Gynecology
Molecular Biology and Gene Regulation

Our lab is investigating the role of mRNA-binding proteins in obesity-related inflammatory processes with a focus on insulin sensitivity and atherosclerosis.


James H. Keen, PhD

James H. Keen, PhD
Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Molecular mechanisms of membrane trafficking in normal and pathological processes using live cell imaging.


yxk016

Yohei Kirino, PhD
Assistant Professor, Biochemistry & Molecular Biology, Computational Medicine Center
Molecular and Cellular Pharmacology, Molecular Biology and Gene Replication

Biogenesis and molecular function of small regulatory RNAs;  piRNA biogenesis and function in germline development; function of microRNA and other small RNAs in cancer development; mitochondrial tRNA biology in mitochondrial diseases.


kxk016

Karen E. Knudsen, PhD
Professor, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling.


lxl028

Lucia R. Languino, PhD
Professor, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Studies of the signaling pathways that contribute to prostate cancer progression and metastasis.


lxm089-

Le Ma, PhD
Associate Professor, Neuroscience
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular and cellular mechanisms of cell shape control, with special interests in the development of axonal and dendritic branches that are critical to neural circuit function and regeneration.


mxm121

My G. Mahoney, PhD
Associate Professor, Dermatology & Cutaneous Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases.


amm104

Alexander M. Mazo, PhD
Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Chromatin modifications by epigenetic factors and nuclear hormone receptors.


sbm001

Steven McMahon, PhD
Professor, Cancer Biology
Molecular Biology and Gene Regulation

Biochemical and genetic pathways regulated by the MYC oncoprotein and the p53 tumor suppressor.


dem103

Diane E. Merry, PhD
Associate Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular pathogenesis of spinal and bulbar muscular atrophy and other polyglutamine expansion diseases; protein misfolding and aggregation in neurodegenerative disease; mouse models of neurologic disease; domain function in trafficking and degradation of the androgen receptor; gene and pharmacological therapies for neurodegenerative diseases.


acm103

Andrea Morrione, PhD
Research Associate Professor, Urology
Chemical and Structural Biology, Molecular Biology and Gene Regulation

Characterization of Insulin-like Growth Factor Receptor I (IGF-IR) and IR-A (insulin receptor isoform A) function in bladder cancer initiation and progression. Role of the growth factor progranulin (proepithelin) and its receptor in bladder cancer. Characterization of the role of adaptor protein Grb10 in the regulation of IGF-IR and IR-A ubiquitination, trafficking, and signaling.


Ulhas P. Naik, PhD

Ulhas P. Naik, PhD
Professor, Medicine
Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Cell-cell interactions and cell-extracellular matrix interactions in cardiovascular diseases and cancer; focus on the molecular mechanisms involved in the regulation of these interactions under physiological and pathophysiological conditions.


mtn006

Marja Nevalainen, MD, PhD
Associate Professor, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Stat transcription factors in prostate cancer.


jmp007

John M. Pascal, PhD
Associate Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Structural biology of DNA replication, repair and signaling mechanisms; mechanisms of genome maintenance and chromosomal metabolism; biochemical and biophysical studies of nucleic ACID enzymes; macromolecular x-ray crystallography


pxp004

Piera Pasinelli, PhD
Associate Professor, Neuroscience
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular mechanisms of motor neuron degeneration and death in amyotrophic lateral sclerosis (ALS); role of superoxide dismutase in cell survival and death; mitochondrial dysfunction in neurodegeneration and neurodegenerative diseases; animal models of ALS; development of cell-based assays for drug screening.


Raymond B. Penn, PhD

Raymond B. Penn, PhD
Professor, Medicine
Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Airway biology; GPCR biology; Asthma pharmacology; Renal transporter biology; Cancer biology; Asthma, COPD, obstructive and fibrotic lung diseases; Chronic metabolic acidosis.


rgp102

Richard G. Pestell, MD, PhD
Professor and Chair, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular mechanisms and gene therapy of breast and prostate cancer; cancer stem cells


Isidore Rigoutsos, PhD

Isidore Rigoutsos, PhD
Professor, Pathology, Anatomy & Cell Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Pattern discovery; motif discovery; regulatory motifs; microRNAs; miRNAs; piRNAs; microRNA and piRNA targeting; non-coding RNAs; RNAi; RNA interference; retrotransposons; cell process regulation; genomics; computational genetics; computational medicine; diagnostics; therapeutics; high-throughput sequencing analysis; microbial genomics; metagenomics; high performance computing.


nar001

Natalia A. Riobo, PhD
Assistant Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Signal transduction mechanisms employed by mammalian Hedgehog proteins in cardiomyoctes, endothelium, cancer cells and stromal fibroblasts in the context of cardiovascular regenerative medicine and cancer.


uxr102

Ulrich Rodeck, MD
Professor, Dermatology & Cutaneous Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Regulation of epithelial cell fate by the epidermal growth factor receptor and associated signal transduction events; molecular mechanisms leading to adverse events of cancer therapy; adverse event reduction by developing drugs targeted to disease sites; zebrafish as an in vivo model system to investigate whole organism genotoxic stress responses.


pxr110

Peter Ronner, PhD
Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology

Control of insulin and glucagon secretion; regulation of ATP-sensitive K channels and voltage-dependent Ca channels; role of cellular metabolism in signal transduction.


mjr111

Michael Root, MD, PhD
Associate Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology

Structure and function of glycoproteins involved in viral and cell-cell membrane fusion; design of viral entry inhibitors and immunogens for vaccine development; antibody-antigen interactions.


hxr001

Hallgeir Rui, MD, PhD
Professor, Cancer Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Signal transduction and biology of prolactin, growth hormone, and JAK-STAT pathways, with a focus on translational research on drug response prediction in human breast cancer.


mjs106

Matthias Schnell, PhD
Professor, Microbiology & Immunology
Molecular Biology and Gene Regulation

Development of novel vaccines and viral pathogenesis

 


cps002

Charles P. Scott, PhD
Assistant Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Combinatorial target and drug discovery; chemical genomics of host-pathogen interactions and cancer.


rss007

Ross Summer, MD
Associate Professor, Medicine, Pulmonary & Critical Care
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.


jxs169

Jianxin Sun, PhD
Associate Professor, Medicine, Center for Translational Research
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Dissecting the molecular mechanisms regulating Endothelial Nitric Oxide Synthase (eNOS) expression and vascular inflammation in the vascular wall.


dxt005

Davide Trotti, PhD
Associate Professor, Neuroscience
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular pathogenesis of amyotrophic lateral sclerosis (ALS); glutamate transporter regulation and excitotoxic mechanisms in neurodegenerative diseases; biophysics of mitochondria conductances in ALS.


jxu102

Jouni Uitto, MD, PhD
Professor and Chair, Dermatology & Cutaneous Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular genetics of the cutaneous basement membrane zone; regulation of collagen and elastin gene expression and the molecular basis of heritable and acquired connective tissue diseases.


Rajanikanth Vadigepalli, PhD

Rajanikanth Vadigepalli, PhD
Associate Professor, Pathology, Anatomy & Cell Biology
Molecular Biology & Gene Regulation

Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology.


saw103

Scott A. Waldman, MD, PhD
Professor and Chair, Pharmacology & Experimental Therapeutics
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer.


pbw101

Philip B. Wedegaertner PhD
Professor, Biochemistry & Molecular Biology
Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation

Heterotrimeric G-protein, Rho GTPase, and Rho guanine-nucleotide exchange factor (RhoGEF) signaling and cell biology; mechanisms and functions of regulated subcellular localization and trafficking.


exw114

Eric Wickstrom, PhD
Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Sensing, imaging, regulation, and control of oncogene expression in cells and animal models with nucleic acid derivatives.


exw109

Edward Winter, PhD
Professor, Biochemistry & Molecular Biology
Chemical and Structural Biology, Molecular and Cellular Pharmacology

Analysis of meiotic development using molecular genetics in yeast; signal transduction and protein kinases; transcriptional regulation.


jxz195

Ji-Fang Zhang, PhD
Professor, Molecular Physiology & Biophysics
Voltage-gated Ca2+ channels (VGCCs) and Ca2+ influx in neuronal signaling, in particular, how Ca2+ influx through different types of Ca2+ channels is able to specifically initiate/regulate different signaling pathways.