Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Molecular Biology & Gene Regulation


Research in Molecular Biology and Gene Regulation broadly investigates the genetic control of cellular physiology in both normal and diseased states. Critical cellular processes dependent on gene transcription and translation are explored at the molecular level using a combination of advanced technical approaches involving recombinant DNA technology, high-throughput genetic analysis, cell culture and model systems, transgenic animals, and high resolution imaging. Research areas include genetic and epigenetic control of gene expression, chromatin structure and function, mechanisms of RNA processing, gene therapy, control of ribosomal protein synthesis, regulation of the cell cycle, and protein folding and misfolding inside the cell. Students who select this area of emphasis gain expertise in a broad range of fundamental methodologies used to investigate cellular mechanisms in the post-genome era.

Areas of Research Principal Investigators
Mechanisms Of Cell Growth And Differentiation Aplin, Calabretta, Jaynes, Kallen, Languino, Ma, Morrione,
Naik, Nevalainen,
 Penn, Pestell, Riobo, Rodeck, 
Rui,  Summer,  Sun,  Vadigepalli, Waldman,
Signal Integration/Cross-Talk Alnemri, Aplin, Calabretta, Eto, Fortini, Hoek, Knudsen, 
Languino, Ma, Mahoney, Morrione, Naik, Nevalainen, Penn, Pestell, 
Riobo, Rodeck, Rui, Schnell, Summer, Sun, Uitto, 
Vadigepalli, Waldman, Wedegaertner, Winter
Protein Targeting And Trafficking Fortini, Morrione, Wedegaertner
Mechanisms Of Programmed Cell Death Fortini, Morrione, Naik, Wedegaertner
Nucleic Acid Biochemistry And Therapeutics Brody, Hou, Jaynes, Kaji, Kirino, Mazo, McMahon, Pascal, 
Rigoutsos, Wickstrom
Cancer Biology Aplin, Brody, Calabretta, Kaji, Kirino, Knudsen, Languino, McMahon, Morrione, Naik, Nevalainen, Penn, Pestell, Rigoutsos, Rodeck, Rui, Waldman
Metabolism And Mitochondrial Function Alnemri, Hoek, Hou, Kallen, Kirino, McMahon, Summer, Waldman
Neurodegenerative And Neuromuscular Diseases Fortini, Hou, Ma, Merry, Pasinelli, Trotti
Genetic Regulation Of Development And Organogenesis Fortini, Hoek, Jaynes,  Kallen, Ma, Mazo, Riobo, Mahoney, Uitto,  Vadigepalli,
Cardiovascular Pharmacology Eto, Naik, Sun
G-Protein Coupled Receptors Naik, Penn, Pestell, Riobo, Wedegaertner
Steroid Hormone Receptors Kallen, Knudsen, Merry, Nevalainen, Rui
Tyrosine Kinase Receptors Morrione, Rodeck, Rui, Wickstrom
Molecular Virology Schnell