Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Chemical & Structural Biology


Research in Chemical and Structural Biology at Jefferson aims to explore the function of biological systems at the molecular level, and to leverage the outcomes of that exploration for the development of novel disease treatments. Important molecular recognition events, such as receptor-ligand and protein-nucleic acid interactions, as well as the molecular mechanisms of catalysis, signal transduction and force generation, are probed using a broad range of biophysical tools, including x-ray crystallography, high-throughput screening, rapid kinetics and high-content imaging. Scientists training within this research emphasis develop a quantitative understanding of key cellular processes that contributes to our fundamental knowledge of human biology and disease.

Areas of Research Principle Investigators
Structural Biology Benovic, Cingolani, Pascal, Root
Mechanisms Of Cell Growth And Differentiation Benovic, Morrione, Rigoutsos, Wickstrom, Winter
Signal Integration/Cross-Talk Benovic, Eto, Holinstat, Keen, Morrione, Penn, Winter
Protein Targeting & Trafficking Benovic, Cingolani, Keen, Morrione, Root, Wedegaertner
Mechanisms Of Programmed Cell Death Scott
Nucleic acid biochemistry and therapeutics Hou, Kaji, Pascal, Morrione, Rigoutsos, Wickstrom,
Pharmacogenomics & Chemical Biology Eto, Hickok, Quong, Rigoutsos, Scott
Cancer Biology Kaji, Morrione, Quong, Scott, Wickstrom
Cardiovascular Pharmacology Eto, Holinstat, Sun
G-Protein Coupled Receptors Benovic, Penn, Wedegaertner,
Tyrosine Kinase Receptors Wickstrom
Imaging Technology Forsberg, Keen, Wickstrom
Molecular Virology Root