Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Molecular & Cellular Pharmacology

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Research in Molecular and Cellular Pharmacology at Jefferson broadly explores the mechanisms of cellular signal transduction pathways and their dysregulation in disease. The interaction of ligands with their receptors and the resultant effects on cellular physiology are probed using state-of-the-art techniques in biochemistry, cell biology, imaging and model organisms. The research focuses on a wide range of cellular signaling molecules, include G protein-coupled receptors, G proteins, receptor tyrosine kinases, intracellular kinases and phosphatases, nuclear hormone receptors, integrins, and proteins involved in apoptosis and membrane trafficking. Discoveries from these laboratories are being actively translated into novel diagnostics and therapeutics in cancer pharmacology, neuropharmacology and cardiovascular pharmacology.

Areas of Research

Principal Investigators

Mechanisms Of Cell Growth & Differentiation

Aplin, Benovic, Languino, Ma, Naik, Nevalainen, Penn, Pestell,
Riobo,
 Rodeck, Rui, Summer,  Sun , Waldman,
Wedegaertner,
 Wickstrom, Winter

Signal Integration/Cross-Talk

Alnemri, Aplin, Benovic, Brainard, Eto, Fortini, Hoek,
Holinstat,
 Keen, Knudsen, Languino, Mahoney, Ma, Naik, Nevalainen, Penn, Pestell, Riobo, Rodeck, Ronner, 
Rui
 Summer,  Sun , Uitto, Waldman, Wedegaertner, Winter, Zhang

Protein Targeting & Trafficking

Benovic, Cingolani, Fortini, Keen, Wedegaertner

Mechanisms Of Programmed Cell Death

Alnemri, Dicker, Farber, Hoek, Pasinelli, Rodeck, Scott

Nucleic Acid Biochemistry & Therapeutics

Brody, Dicker, Hou, Kaji, Kirino, Mazo, Naik, Pascal,  Rigoutsos, Wickstrom

Cancer Biology

Aplin, Brody, Dicker, Farber, Kaji, Kirino, Knudsen, 
Languino,
Naik, Nevalainen, Penn, Pestell, Rigoutsos,
Rodeck,
 Rui, Scott, Waldman, Wickstrom

Metabolism & Mitochondrial Function

Alnemri, Cingolani, Farber, Hoek,
Holinstat, Hou, Kirino, Rigoutsos, Ronner, Summer, 
Waldman

Neurodegenerative & Neuromuscular Diseases

Dalva, Fortini, Hou, Ma,
Merry, Pasinelli, Trotti

Genetic Regulation Of Development & Organogenesis

Fortini, Hickok, Hoek, Ma, Mazo, Riobo, Winter, 
Mahoney,
 Uitto

Structural Biology

Benovic, Cingolani, Pascal

Cardiovascular Pharmacology

Eto, Holinstat, Naik, Sun

G-Protein Coupled Receptors

Benovic, Naik, Penn, Pestell, Riobo, Wedegaertner

Steroid Hormone Receptors

Knudsen, Merry, Nevalainen, Rui

Tyrosine Kinase Receptors

Rodeck, Rui, Wickstrom