Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Faculty

A

Eleni Anni, PhD

Eleni Anni, PhD
Associate Professor

E. Aplin, PhD

Andrew E. Aplin, PhD
Professor
Targeting mutant BRAF and integrin signaling in melanoma.

Hwyda Arafat, MD, PhD

Hwyda Arafat, MD, PhD
Associate Professor
Co-Director, Jefferson Pancreas, Biliary & Related Cancer Center
My laboratory is currently investigating the molecular mechanisms involved in the regulation of oxidative stress and inflammation signaling in two pancreatic diseases, type 1 diabetes and pancreatic cancer.

Sophie Astrof, PhD

Sophie Astrof, PhD
Assistant Professor
The main focus of my lab is to understand cellular and molecular mechanisms of cardiovascular development in vertebrates.

B

Jonathan Brody, PhD

Jonathan Brody, PhD
Assistant Professor
Director, Surgical Research
Novel therapeutic strategies for pancreatic cancer patients; primarily focused on HuR biology as it relates to the clinical management of cancer, including identifying clinically relevant HuR targets.

C

Mark T. Curtis, MD, PhD

Mark T. Curtis, MD, PhD
Associate Professor
Viral Diseases of the Central Nervous System
Demyelinating Disorders of the Central Nervous System

D

Paul J. Dimuzio, MD, FACS

Paul J. Dimuzio, MD, FACS
Associate Professor
Vascular and Endovascular Surgery, including: Carotid artery disease, Aneurysms of the thoracic and abdominal aorta, Peripheral vascular disease, Venous disease, Thoracic outlet syndrome

E

Leonard M. Eisenman, PhD

Leonard M. Eisenman, PhD
Professor
Structure and function of the cerebellum

Motomi Enomoto-Iwamoto, PhD, DDS

Motomi Enomoto-Iwamoto, PhD, DDS
Associate Professor

F

Bruce A. Fenderson, PhD

Bruce A. Fenderson, PhD
Professor
Mechanisms of morphogenesis and malignancy; role of cell-surface carbohydrates in mediation of cell recognition during development; use of monoclonal anticarbohydrate antibodies to study lineage formation, cell differentiation, and neoplastic transformation.

 

Andrzej Fertala, PhD

Andrzej Fertala, PhD
Professor
My primary research activities involve the area of extracellular matrix. In particular, my studies focus on (i) identifying pathomechanisms of heritable diseases of connective tissues caused by mutations in collagen genes, (ii) technologies to produce novel collagen-like proteins for biomedical applications, and (iii) developing novel approaches to limit excessive fibrosis.

Theresa A. Freeman, PhD

Theresa A. Freeman, PhD
Associate Professor
The areas of research focus within my laboratory can be divided into 3 main areas: Osteoarthritis, Reactive Oxygen Species (ROS) in Chondrocyte Differentiation and Cartilage Degeneration, and Non-Thermal Plasma activation of Cellular Differentiation for Tissue Regeneration

G

Gerald B. Grunwald, PhD

Gerald B. Grunwald, PhD
Dean, Jefferson Graduate School of Biomedical Sciences
Professor, Pathology, Anatomy & Cell Biology
Developmental biology and neuroscience; eye development and disease, analysis of the role of cadherin cell adhesion molecules in normal and abnormal embryonic development and in proliferative diseases of the nervous mechanisms of cadherin expression and function.

H

Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD
Professor
Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Noreen J. Hickok, PhD

Noreen J. Hickok, PhD
Associate Professor
Development of surfaces for combating implant-associated infection; bacterial-osteoblastic cell interactions; role of extracellular bone matrix in bone formation, bacterial adhesion, and latent infections.

Jan B. Hoek, PhD

Jan B. Hoek, PhD
Interim Director, Cell and Developmental Biology Graduate Program
Professor & Vice Chair
Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.

I

Lorraine Iacovitti, PhD

Lorraine Iacovitti, PhD
Professor
Neurodegenerative Diseases, Stem Cells, Parkinson's Disease

Renato V. Iozzo, MD

Renato V. Iozzo, MD
Professor
Director, Extracellular Matrix Program
Professor of Pathology and Cell Biology, and Director of the Extracellular Matrix Program at the Kimmel Cancer Center, Thomas Jefferson University.

Masahiro Iwamoto, DDS, PhD

Masahiro Iwamoto, DDS, PhD
Associate Professor

J

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Jean F. Jasmin, PhD
Assistant Professor (Tenure-Track)
Caveolin-mimetic peptides for the treatment of pulmonary hypertension.

James B. Jaynes, PhD

James B. Jaynes, PhD
Professor
Basic, clinical and translational research on cognitive and motor aspects of Parkinson's disease with focuses on both symptomatic and neuroprotective treatment strategies; basic and clinical research on developmental neurotoxicology with an emphasis on lead-induced damage to the brain.

Bing-Hua Jiang, PhD

Bing-Hua Jiang, PhD
Professor
Molecular mechanisms of PI3K, HIF-1, and VEGF signaling pathways in angiogenesis and tumorigenesis

Suresh K. Joseph, PhD

Suresh K. Joseph, PhD
Professor
Molecular mechanisms of PI3K, HIF-1, and VEGF signaling pathways in angiogenesis and tumorigenesis

K

Hideko Kaji, PhD

Hideko Kaji, PhD
Professor
Translation (protein synthesis) from aminoacyl tRNA consists of four consecutive steps; initiation, elongation, termination, and recycling of the machinery of the protein synthesis for the next round of translation.

M

Alexander M. Mazo, PhD

Alexander M. Mazo, PhD
Professor
Transcriptional Regulation by Epigenetic Factors and Nuclear Hormone Receptors

 

 

Steven B. McMahon, PhD

Steven B. McMahon, PhD
Professor
Our group has a long-standing interest in understanding the biochemical events that are deregulated to cause alterations in broad transcriptional programs in human cancer.

 

A. Sue Menko, PhD

A. Sue Menko, PhD
Professor
Role of integrins in the regulation of cell differentiation: Integrin signalling of cell differentiation events, particularly integrin-growth factor receptor coordinated signalling.

 

Diane E. Merry, PhD

Diane E. Merry, PhD
Associate Professor
How does expansion of the polyglutamine tract in the androgen receptor cause motor neuron dysfunction and cell death?

P

Maurizio Pacifici, PhD

Maurizio Pacifici, PhD
Professor
Dr. Pacificis biomedical research work focuses on mechanisms controlling skeletal development and growth in fetal and postnatal life.

 

Javad Parvizi, MD, FRCS

Javad Parvizi, MD, FRCS
Vice Chairman, Clinical Research
Professor
Dr. Parvizi is a board certified orthopaedic surgeon specializing in pelvis, hip, and knee reconstruction with a special interest in hip pain in young adults and joint preservation procedures.

Fabienne Paumet, PhD

Fabienne Paumet, PhD
Assistant Professor
Molecular mechanisms of phagocytosis: how do pathogens subvert this process?

 

Stephen C. Peiper, MD

Stephen C. Peiper, MD
Peter A. Herbut Professor and Chair

 

 

Karsten Peppel, PhD

Karsten Peppel, PhD
Associate Professor
The current research in my lab seeks to further our understanding of the role of inflammation in vascular pathology.


Richard G. Pestell, MD, PhD

Richard G. Pestell, MD, PhD
Professor and Chairman, Department of Cancer Biology
Director, Kimmel Cancer Center br> Molecular mechanisms and gene therapy of breast and prostate cancer.

R

Glenn Radice, PhD

Glenn Radice, PhD
Associate Professor
The Radice laboratory investigates the function of cadherins, a family of cell adhesion molecules, critical for the establishment and maintenance of tissue structure.

 

Natalia Riobo, PhD

Natalia Riobo, PhD
Assistant Professor
My interest is to understand the role of the each pathway activated by Hedgehogs in biologically relevant processes.

 

Makarand V. Risbud, PhD

Makarand V. Risbud, PhD
Professor
Major research focus of my lab is to study the mechanisms by which nucleus pulposus cells of the intervertebral disc adapt to avascular (hypoxic) and osmotically compromising environment.

 

Michael Root, MD, PhD

Michael Root, MD, PhD
Associate Professor
My laboratory studies the mechanism of HIV entry and its inhibition. HIV cellular invasion begins with fusion of the viral and cellular membranes, a process mediated by the viral envelope glycoprotein complex gp120/gp41.

 

Abdolmohamad Rostami, MD, PhD

Abdolmohamad Rostami, MD, PhD
Professor & Chairman, Department of Neurology
My research focuses on... Multiple Sclerosis is an autoimmune disease of the central nervous system that affects over 400,000 Americans and over 2 million worldwide. My research focuses on the pathogenesis of multiple sclerosis using the animal model of this disease, experimental autoimmune encephalomyelitis (EAE). At the present, we are focusing ...

Hallgeir Rui, MD, PhD

Hallgeir Rui, MD, PhD
Professor
Dr. Rui has made a series of contributions to increased understanding of the molecular mechanisms of signal transduction by receptors for prolactin and related cytokines and hormones.

S

Jay S. Schneider, PhD

Jay S. Schneider, PhD
Professor
Research interest is a combination of monocarboxylate transporters; CD147; retinal pigmment epithelium; retinal metabolism; glycolysis, and JAM-C

 

James S. Schwaber, PhD

James S. Schwaber, PhD
Associate Professor
Dr. Schwaber uses systems biology approaches in mammalian brain to study adaptive neuronal processes.

 

Erin L. Seifert

Erin L. Seifert
Assistant Professor

 



Irving M. Shapiro, BDS, PhD

Irving M. Shapiro, BDS, PhD
Gertrude and Anthony DePalma Professor, Orthopaedic Surgery
Director Division, Orthopaedic Research
Director, Tissue Engineering & Regenerative Medicine Training Program
Mechanism of Bone Growth and Repair: Despite decades of study, the mechanism by which a thin layer of cartilage, the epiphyseal growth plate, regulates long bone growth remains poorly understood.

Linda D. Siracusa, PhD

Linda D. Siracusa, PhD
Professor
The study of genes that influence complex traits is a rapidly evolving field. The power of mammalian genetics coupled with the ability to scan entire genomes of individual animals has led to the discovery of chromosomal regions that harbor genes conferring susceptibility or resistance to different cancers.

T

Theodore F. Taraschi, PhD

Theodore F. Taraschi, PhD
Professor
Vice Chair for Education
The invasion of erythrocytes by Plasmodium falciparum parasites produces aninfection that causes major changes in the structure, composition, antigenicity and function of the host cell membrane.

U

Jouni J. Uitto, MD, PhD

Jouni J. Uitto, MD, PhD
Professor & Chair
Professor of Biochemistry and Molecular Biology
Director, Jefferson Institute of Molecular Medicine
Dr Uitto is internationally recognized for his research on connective tissue biochemistry and molecular biology in relation to cutaneous diseases and skin aging.

V

Rajanikanth Vadigepalli, PhD

Rajanikanth Vadigepalli, PhD
Research Assistant Professor
Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology.

 

W

Scott A. Waldman, MD, PhD

Scott A. Waldman, MD, PhD
Professor
Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer.

Zi-Xuan (Zoe) Wang, PhD

Zi-Xuan (Zoe) Wang, PhD
Clinical Assistant Professor
My research interests are concentrated on geonomic and personalized medicine.



Philip B. Wedegaertner, PhD

Philip B. Wedegaertner, PhD
Professor
Research in this lab focuses on understanding G protein signaling. The heterotrimeric G proteins, composed of alpha-beta-gamma subunits, function as molecular switches.



Edward Winter, PhD

Edward Winter, PhD
Professor
Defects in meiotic regulation are a significant cause of infertility, birth defects, spontaneous abortion, and disease.



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