Thomas Jefferson UniversityJefferson Graduate School of Biomedical Sciences

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Faculty

David Abraham, PhD

David Abraham, PhD
Professor, Microbiology & Immunology

Parasite immunology; role of eosinophils, neutrophils, and macrophages in innate and adaptive immunity to helminth parasite infections; development of vaccines against nematode infections; genetic control of protective immunity to parasites; chemotherapy of leishmaniasis; diagnosis of strongyloidiasis.

Kishore Alugupalli, PhD

Kishore Alugupalli, PhD
Assistant Professor, Microbiology & Immunology

Molecular basis of bacterial pathogenesis using murine infection models; B 1 b lymphocytes in T cell–independent IgM memory; role of Toll-like receptors in innate and adaptive immune responses.

 

Catherine Calkins, PhD

Catherine Calkins, PhD
Professor, Microbiology & Immunology

Cellular immunology; immunoregulation of antiself reactivity; autoimmune disease; autoimmune hemolytic anemia; antiviral immunity; immunopathogenesis of hepatitis B virus.

 

Kerry S. Campbell, PhD

Kerry S. Campbell, PhD
Adjunct Research Associate Professor, Microbiology & Immunology
Fox Chase Cancer Center

Molecular mechanisms by which killer cell immunoglobulin-like receptors (KIR)regulate human natural killer (NK) cell responses; signal transduction in natural killer cells.

 

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Laurence C. Eisenlohr, VMD, PhD
Professor, Microbiology & Immunology

Cell biology of MHC class I– and class II–restricted antigen processing of viral antigens; T-cell responses and memory to viral antigens; vaccinology; antitumor immunity.

 

 	Phyllis Flomenberg, MD

Phyllis Flomenberg, MD
Associate Professor, Medicine

Adenoviruses; Vaccinia virus; viral immunology; tumor immunology; immunotherapy.

 

Richard Hardy, PhD

Richard Hardy, PhD
Adjunct Research Professor, Microbiology & Immunology
Fox Chase Cancer Center

Developmental immunology of B cells, including their generation from stem cells in fetal liver and bone marrow; regulation of B-cell development by pre-BCR and BCR signaling; development of B-cell subsets, including B-1 B cells, with relevance to autoimmunity
                                 and leukemia.

D. Craig Hooper, PhD

D. Craig Hooper, PhD
Associate Professor, Cancer Biology

Neuroimmunology; virus clearance from the central nervous system (CNS); CNS tumor immunity; regulation of blood-brain barrier function; immune effector delivery into the CNS; CD4 T-cell priming; inflammation; autoimmunity; immunopathogenesis; contribution of free radicals to immunity; CNS vaccine development.

Tim Manser, PhD

Tim Manser, PhD
Professor and Chairperson, Microbiology & Immunology

Role of antigen receptor specificity in B-cell selection, tolerance, and memory; germinal center reaction; regulation of B-cell responses by inhibitory Fc receptors.

 

James P. McGettigan, PhD

James P. McGettigan, PhD
Assistant Professor, Microbiology & Immunology

Investigating vaccine-induced T and B cell responses against viral infections.

 

Steven E. McKenzie, MD, PhD

Steven E. McKenzie, MD, PhD
Professor, Medicine and Pediatrics

Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes.

 

Fabienne M. Paumet, PhD

Fabienne M. Paumet, PhD
Assistant Professor, Microbiology & Immunology

Role of phagocytosis in the pathogenesis of infectious diseases; Role of phagocytosis in mast cell function in allergy

 

Richard G. Pestell, MD, PhD

Richard G. Pestell, MD, PhD
Professor & Chairperson, Cancer Biology

Molecular mechanisms and gene therapy of breast and prostate cancer; cancer stem cells.

 

Glenn Rall, PhD

Glenn Rall, PhD
Adjunct Research Associate Professor, Microbiology & Immunology
Fox Chase Cancer Center

Viral spread within neurons; recruitment and function of the immune response to neurotropic viral challenges; transgenic models of viral pathogenesis.

Ulrich Rodeck, MD, PhD

Ulrich Rodeck, MD, PhD
Professor, Dermatology & Cutaneous Biology

Regulation of epithelial cell fate by the epidermal growth factor receptor and associated signal transduction events; molecular mechanisms leading to adverse events of cancer therapy; adverse event reduction by developing drugs targeted to disease sites; zebrafish as an in vivo model system to investigate whole organism genotoxic stress responses.

Michael J. Root, MD, PhD

Michael J. Root, MD, PhD
Associate Professor, Biochemistry & Molecular Biology

Mechanisms of viral and cell-cell membrane fusion; HIV entry inhibitor design and vaccine development; Osteoclast formation/macrophage fusion

 

Abdolmohamad Rostami, MD, PhD

Abdolmohamad Rostami, MD, PhD
Professor & Chairperson, Neurology

Neuroimmunology, etiology and pathogenesis of multiple sclerosis (MS) role of Th1 and Th17 cells in the pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE) and MS; role of IL-27 and GM-CSF in EAE and MS pathogenesis; mechanisms of tolerance induction in autoimmune inflammation of CNS.

Takami Sato, MD, PhD

Takami Sato, MD, PhD
Professor, Medical Oncology

Cancer immunotherapies; immunoembolization of hepatic metastasis from uveal melanoma with GM-CSF, adaptive immunotherapy with natural killer cell, IL-10 immunoadhesin.

 

Matthias J. Schnell, PhD

Matthias J. Schnell, PhD
Professor, Microbiology & Immunology

Development of novel vaccines and viral pathogenesis; recombinant rhabdoviruses as vaccine vectors for HIV-1 and other infectious diseases; interaction of rhabdoviruses with the immune system; molecular pathogenesis of rabies virus.

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Luis Sigal, DVM, PhD
Adjunct Associate Professor, Microbiology & Immunology
Fox Chase Cancer Center

Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus.

Linda D. Siracusa, PhD

Linda D. Siracusa, PhD
Professor, Microbiology & Immunology

Genetics of cancer susceptibility: identification and characterization of genes, allelic variants, and mutations involved in mammalian tumorigenesis.

 

Christopher Snyder, PhD

Christopher Snyder, PhD
Assistant Professor, Microbiology & Immunology

Viral immunology; maintenance of adaptive immunity during chronic infections; T cell responses elicited by cytomegalovirus infection; activation of T cell effector functions by innate signals.

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Ross Summer, MD
Associate Professor, Medicine, Pulmonary & Critical Care

Lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.

 

Yuri K. Sykulev, MD, PhD

Yuri K. Sykulev, MD, PhD
Professor, Microbiology & Immunology

Molecular mechanisms regulating cytotoxic T lymphocyte activity.

 

Theodore F. Taraschi, PhD

Theodore F. Taraschi, PhD
Professor, Pathology, Anatomy & Cell Biology

Role of defective DNA mismatch repair in the development of antimalarial drug resistance

 

Scott A. Waldman, MD, PhD

Scott A. Waldman, MD, PhD
Professor and Chairperson, Pharmacology & Experimental Therapeutics

Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer.

David Wiest, PhD

David Wiest, PhD
Adjunct Associate Professor, Microbiology & Immunology
Fox Chase Cancer Center

Understanding the molecular basis for control of T lineage development by molecular effectors differentially elicited by distinct TCR isotypes.

Jianke Zhang, PhD

Jianke Zhang, PhD
Associate Professor, Microbiology & Immunology

Immune tolerance and homeostasis; lymphocyte apoptosis; cytokine-receptor signal transduction; lymphocyte development; signal transduction mechanisms by the Fas/TNF receptor family members that mediate apoptosis and growth/proliferation; Toll-like receptor signaling; transgenic and gene targeting (knockout) analyses of protein functions in mice.