Thomas Jefferson UniversitySidney Kimmel Medical College

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Current Projects

Evaluation of the GluMetrics GluCath Intravascular Continuous Glucose Monitoring Sensor
Sponsor GluMetrics Corporation
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Lui, MD
Description Animal study to evaluate a continuous intravascular glucose monitoring system for 24 to 48 hours.
Evaluation of Animas Continuous Subcutaneous Insulin Infusion Catheter
Sponsor Animas Corporation (Johnson & Johnson Company)
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Lui, MD, Peter McCue, MD
Description Animal study to evaluate a new continuous subcutaneous tissue insulin infusion (CSII) catheters over 5 days of use.
Hospital Feasibility 2:  A Feasibility Evaluation of the Medtronic Hospital Glucose Management System (HGMS) in Critically Ill Adult Subjects
Sponsor Medtronic Diabetes
Investigators Jeffrey Joseph, DO, David Gratch, DO, Brian Hipszer, PhD, Murray Cohen, MD, Michael Weinstein, MD
Description The subcutaneous tissue continuous glucose monitoring system being developed by Medtronic is being evaluated in hospitalized patients managed in the ICU.
A Pilot Study to Evaluate the Accuracy of Subcutaneous Tissue Interstitial Fluid         Continuous Glucose Monitoring Sensors Developed by Medtronic Minimed in Diabetic Volunteers during Mild Hyperglycemia and Hypoglycemia
Sponsor Medtronic Diabetes
Investigators Jeffrey Joseph, DO, Boris Mraovic, MD, Serge Jabbour, MD, Brian Hipszer, PhD
Description The subcutaneous tissue continuous glucose monitoring system being developed by Medtronic for use in the hospital is being evaluated in diabetic volunteers using a hypoglycemia clamp protocol.
Statistical Functional Data Analysis Models of Glucose and Insulin Kinetics
Sponsor National Institutes of Health NIH/NIDDK (1R21DK081088-01A1)
Investigators Inna Chervoneva, PhD,,, Brian Hipszer, PhD, Jeffrey Joseph, DO, Tanya Atanasovich, PhD
Description Secondary analyses of data collected in clinical studies to develop subject-specific statistical models for population-based analysis of glucose metabolism with application to glucose management of diabetic patients.
Evaluation of Continuous Glucose Monitoring Technologies
Sponsor Teleflex Incorporated
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD
Description Evaluation of continuous glucose monitoring systems for in-hospital use.
Correlation Between Hyperglycemia and Glycosuria in Surgical Patients
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Zvi Grunwald, MD,  Brian Hipszer, PhD, Inna Chervoneva, PhD, David Gratch, DO, Intekab Ahmed, MD
Description Human clinical trial to correlate changes in a surgical patient’s BG level with the rate of urine production, urine color, urine specific gravity, and the urine glucose concentration.
Observational Study of Recurrent Hypoglycemia in Hospitalized Patients using a Continuous Glucose Monitoring System
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Zvi Grunwald, MD, Kevin Furlong, DO, Photi Galanis, MD, Nathan Negin, MD, Rachael Sorokin, MD, Brian Hipszer, PhD, Inna Chervoneva, PhD,
Description Two Medtronic CGMS iPro Recorders are used to measure the subcutaneous tissue interstitial fluid glucose concentration every 5 minutes for 3 to 6 days in hospitalized patients at high-risk for hypoglycemia.
Observational Study of a Continuous Glucose Monitoring System During Labor, Delivery, and Post-partum
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Michelle Beam, DO,, Jane Huffnagle, DO, Jeffrey Joseph, DO, Suzanne Huffnagle, DO, Brian Hipszer, PhD, Michele Mele, MD, Elia Elia, MD, Wlodzimierz Grodecki, MD
Description Medtronic CGMS iPro Glucose Recorder glucose measurements will be compared to the standard hospital glucose measurement method (fingerstick capillary blood sample and Accu-Chek glucose meter and strip). Glucose sensor accuracy will be evaluated during labor, delivery, and post-partum.
Economic Cost of Hypoglycemia
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Boris Mraovic, MD, Rachael Sorokin, MD
Description A nurse survey and an Accu-Chek database analysis will be used to determine the economic cost of diagnosing and treating hypoglycemia at Thomas Jefferson University Hospital (TJUH)