Thomas Jefferson UniversityJefferson Medical College

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Past Projects

Observational Clinical Study of the Intravenous Blood Glucose System in Hospitalized Adult Elective or Non-Emergent Surgery and Medical/Surgical Intensive Care Unit Patients
Sponsor Edwards Lifesciences and DexCom Coporation
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD., Zvi Grunwald, MD, Charles Yeo, MD, Boris Mraovic MD, David Gratch, DO
Description Human trial to evaluate intravenous blood glucose monitoring system in hospitalized patients in OR and ICU.
Research, Development, In-Vitro Testing, & In-Vivo Testing of Automated Blood Sampling System
Sponsor Hospira Inc.
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Liu, MD
Description Laboratory and animal studies to develop, test, and optimize automated blood sampling system attached to an intravenous catheter for glucose monitoring in the hospital.
An Unblinded, Non-Randomized Study to Evaluate the Accuracy of the Sentris-100 in Type One and Type Two Diabetic Subjects during Induced Hypoglycemia
Sponsor GlucoLight Corporation
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Intekab Ahmed, MD, Jennifer Lessin, RN
Description Human clinical trial to evaluate a non-invasive glucose monitor during induced hypoglycemia in volunteer subjects with type 1 and type 2 diabetes
pH Sensitive Complex Hydrogels for Protein Drug Release
Sponsor National Institutes of Health NIH/NIDDK (RO1GM43337-08A1)
Investigators Jeffrey Joseph, DO, Nicholas Peppas, PhD (Purdue University), Anthony Lowman, PhD (Drexel University)
Description Development and pharmacokinetic studies of novel hydrogel formulations for the controlled delivery of insulin from the GI tract into systemic circulation were conducted.
Blood Sample Acquisition from a Peripheral Venous Catheter:  Comparing the Single-Stopcock Method to the Venous Arterial Blood Management Protection System Method (VAMP Plus)
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Boris Mraovic, MD, Zvi Grunwald, MD
Description Clinical trial in diabetic and non-diabetic volunteers to compare success of repeat blood sample acquisition from a stopcock or a VAMP system.
Comparison of Glucose Levels in Simultaneous Samples of Arterial, Capillary, and Venous Blood
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Jeremy Flood, MD, Larry Kim, MD, Brian Hipszer, PhD, Steven McNulty, DO, Inna Chervoneva, PhD, James Diehl, MD, Scott Silvestry, MD
Description The glucose concentration of blood simultaneous sampled from a radial artery catheter, central venous catheter, and capillary fingerstick were compared using an Accu-Chek glucose meter and strips.
Development and Testing of an Implantable Near-infrared Blood Glucose Sensor
Sponsor Animas Corporation
Investigators Jeffrey Joseph, DO, Marc Torjman, PhD, Barry Goldstein, MD, PhD, Brian Hipszer, PhD, Michael Moritz, MD, Peter McCue, MD, Ronald Jensh, PhD , Paul Dimusio, MD, Neils Martin, MD
Description Laboratory, human blood, and animal studies to develop and test a long-term implantable near-infrared blood glucose monitoring system.
Artificial Pancreas for Control of Blood Glucose and Insulin Levels in Hospitalized Patients with Diabetes and Stress Hyperglycemia
Sponsor Department of Defense: Technology for Metabolic Monitoring Program
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Zvi Grunwald, MD, Charles Yeo, MD, David Gratch, DO, James Heitz, MD, David Maguire, MD, Barry Goldstein, MD
Description Intravenous and interstitial fluid glucose sensors developed by Medtronic Inc. were evaluated in ten patients hospitalized for major surgery. One intravenous sensor and six interstitial fluid sensors were evaluated in each patient for 60 hours and compared to reference blood glucose measurements.
An Implantable Near-IR Glucose Sensor
Sponsor National Institutes of Health NIH/NIDDK (R01-DK55246-01)
Investigators Jeffrey Joseph, DO, Katherine Crothall, PhD (Animas Corporation), Marc Torjman, PhD, Barry Goldstein, MD, PhD, Michael Moritz, MD, Paul Dimusio, MD, Neils Martin, MD, Patrick Schaner, MD, Brian Hipszer, PhD, Maxim Soloviev, MD, PhD, Mark Destephano, Luis Jahn, PhD, Yizhong Yu, PhD
Description Development and testing of an implantable optical blood glucose monitoring system in diabetic humans and diabetic animals.
Long-term Implantable Optical Blood Glucose Monitor
Sponsor National Institute of Standards and Technology (NIST) Advanced Technology Award
Investigators Jeffrey Joseph, DO, Mark Destephano (Animas Corporation), Marc Torjman, PhD, Barry Goldstein, MD, PhD, Brian Hipszer, PhD, Paul Dimusio, MD, Katherine Crothall, PhD, Luis Jahn, PhD, Yizhong Yu, PhD
Description Development and testing of a long-term implantable intravascular optical blood glucose sensor in animals and humans
Retrospective Review of Blood Glucose Level and Patient Outcome following Total Knee and Hip Replacement Surgery
Sponsor Lifescan Inc., a Johnson and Johnson Company
Investigators Jeffrey Joseph, DO, Boris Mraovic, MD, Zvi Grunwald, MD, Inna Chervoneva, PhD, Javid Parvizi, MD, Richard Rothman, MD, Brian Hipszer, PhD
Description Retrospective review of the TJU Hospital database and orthopedic surgery database to determine whether there is a correlation between glucose control and infection, other adverse events and mortality in patients undergoing total knee/hip replacement therapy. Analysis reviewed a correlation between pre-operative hyperglycemia and mortality, length of stay, and incidence of pulmonary embolism.
Blood Glucose Level Determination Based on Intracardiac Electrogram Signals
Sponsor St. Jude Medical Corporation
Investigators Jeffrey Joseph, DO, Brian Hipszer, PhD, Arnold Greenspon, MD, and David Maguire, MD
Description A human clinical trial was performed to determine whether intracardiac pacemaker and surface electrogram signals could be used to detect the onset of hypoglycemia.  An algorithm was developed to detect hypoglycemia based upon changes in the pacemaker’s electrogram signal.
Determination of Radial Artery Catheter Failure Modes using Ultrasound and  Physical Examination
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Vincent Franze, DO, Jeffrey Joseph, DO, Dejan Vuckovic, MD, David Gratch, DO, Zvi Grunwald, MD, Boris Mraovic, MD, and Larry Needleman, MD
Description Hospital clinical trial using color-flow ultrasound to evaluate radial artery anatomy and blood flow before and after insertion of a radial artery catheter.
Capillary Interface Drug Delivery Device- Implantable Catheter for Controlled Insulin Delivery- “CID3”
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph, DO, Marc Torjman, PhD, Anita Mohandas, Brian Hipszer, PhD, A Shapiro, PhD, Anthony Lowman, PhD
Description Development of a long-term implantable insulin delivery catheter that utilizes tissue engineering techniques to grow and maintain a high density capillary network adjacent to the site of drug delivery (CID3- capillary interface drug delivery device).  Insulin is rapidly and completely absorbed from the CID3, providing precise on-off control of plasma insulin levels.
Implantable Arterial Tonometer to Continuously Monitor the Arterial Pressure Waveform in Ambulatory Humans
Sponsor Anesthesiology Research and Education Fund at Thomas Jefferson University
Investigators Jeffrey Joseph DO, Brian Hipszer, PhD, Stephen McNulty, DO, Ryzard Lec, PhD, Mareck Swoboda, PhD
Description Development of a long-term implantable sensor (tonometer) that couples an array of force transducers to the outside wall of a small artery- to measure the blood pressure waveform with each beat of the heart.
Evaluation of the VIA-GLU Monitor for Real-time Blood Glucose Monitoring
Sponsor Metracor Corporation
Investigators Jeffrey Joseph, DO, Arjuan Ganesh, PhD, Brian Hipszer, PhD, Navdeep Loomba, MD, Marc Torjman, PhD
Description Evaluation of the VIA Blood Chemistry Monitor for Glucose in healthy and diabetic volunteers.
A Comparison of Glycaemic Variability in CSII vs. MDI Treated Type 1 Diabetic Patients Using CGMS
Sponsor Medtronic Inc
Investigators Barbara Simons, MD, Vanita Treat, MD, Cheryl Marco, RN, Daniel Rosenberg, MD, Jeffrey Joseph, DO, Brian Hipszer, PhD, Y Li, MD, Inna Chervoneva, PhD, L Padron-Massara, MD, Serge Jabbour, MD
Description Evaluation of glucose variability using a continuous glucose monitoring system in T1DM patients managed with CSII or MDI
Diurnal variation of the human adipose transcriptome and the link to metabolic disease
Sponsor Merck, Inc.
Investigators Loboda A, Kraft W, Fine B, Joseph J, Nebozhyn M, Zang C, He, Xia Yang Y, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson, Lamb J, Dai H,  Schadt E, Greenberg H, Yee Lum
Description Adipose tissue was removed from human volunteers before and after oral diabetes medication to determine the effects of drug timing on transcription and translations