111C Alnemri, Emad - Thomas Jefferson University - Thomas Jefferson University

Emad Alnemri, PhD

Contact Dr. Alnemri

233 S. 10th Street
904 BLSB
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Most Recent Peer-reviewed Publications

  1. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  2. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
  3. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  4. IKK╬▒ negatively regulates ASC-dependent inflammasome activation
  5. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  6. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  7. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  8. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  9. A novel role for the mitochondrial HTRA2/OMI protease in aging
  10. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  11. Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
  12. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  13. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
  14. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  15. Cutting edge: Mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
  16. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
  17. Sensing cytoplasmic danger signals by the inflammasome
  18. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
  19. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 Identified in an atypical autoinflammatory disorder
  20. Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome