esa101

Emad Alnemri, PhD

Contact Dr. Alnemri

233 S. 10th Street
904 BLSB
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Most Recent Peer-reviewed Publications

  1. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  2. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  3. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  4. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  5. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  6. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
  7. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  8. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
  9. IKK╬▒ negatively regulates ASC-dependent inflammasome activation
  10. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  11. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  12. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  13. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  14. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  15. A novel role for the mitochondrial HTRA2/OMI protease in aging
  16. Translation termination factor eRF3 is targeted for caspase-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis
  17. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  18. Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
  19. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  20. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes