0B68 Freedman, Leonard P. - Thomas Jefferson University - Thomas Jefferson University

Leonard P. Freedman, PhD

Contact Dr. Freedman

1025 Walnut Street,
100 College
Philadelphia, PA 19107

(215) 955-2012

Most Recent Peer-reviewed Publications

  1. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes
  2. Identification of 5α,6α-epoxycholesterol as a novel modulator of liver X receptor activity
  3. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology
  4. Estrogen receptor β is a novel therapeutic target for photoaging
  5. Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase (Molecular and Cellular Biology (2007) 27, 5, (1904-1913))
  6. Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of β-catenin
  7. Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination
  8. The skinny on fat: How oxysterols may regulate functional glucocorticoids in adipose tissue
  9. Liver X receptor is a therapeutic target for photoaging and chronological skin aging
  10. MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways
  11. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
  12. Signaling by estrogens
  13. A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling
  14. Selective androgen receptor modulators for frailty and osteoporosis
  15. Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase
  16. Vitamin D receptor ligands for osteoporosis
  17. Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy
  18. Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
  19. Antagonist-induced, activation function-2-independent estrogen receptor α phosphorylation
  20. Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity