yxh103

Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. Methyl transfer by substrate signaling from a knotted protein fold
  2. Molecular basis and consequences of the cytochrome c-tRNA interaction
  3. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression
  4. Kinetic Analysis of tRNA Methyltransferases
  5. Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
  6. The UGG isoacceptor of tRNAPro is naturally prone to frameshifts
  7. Maintenance of protein synthesis reading frame by EF-P and m 1 G37-tRNA
  8. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  9. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  10. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
  11. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  12. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  13. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  14. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  15. The selective tRNA aminoacylation mechanism based on a single G.U pair
  16. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  17. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  18. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  19. Conservation of structure and mechanism by Trm5 enzymes
  20. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process