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Ya-Ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria
  2. Methyl transfer by substrate signaling from a knotted protein fold
  3. Molecular basis and consequences of the cytochrome c-tRNA interaction
  4. A novel HSD17B10 mutation impairing the activities of the mitochondrial Rnase P complex causes X-linked intractable epilepsy and neurodevelopmental regression
  5. Kinetic Analysis of tRNA Methyltransferases
  6. Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
  7. The UGG isoacceptor of tRNAPro is naturally prone to frameshifts
  8. Maintenance of protein synthesis reading frame by EF-P and m 1 G37-tRNA
  9. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  10. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  11. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
  12. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  13. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  14. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  15. The selective tRNA aminoacylation mechanism based on a single G.U pair
  16. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  17. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  18. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  19. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  20. Conservation of structure and mechanism by Trm5 enzymes