27FA Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University
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Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  2. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  3. The selective tRNA aminoacylation mechanism based on a single G.U pair
  4. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  5. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  6. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  7. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  8. Conservation of structure and mechanism by Trm5 enzymes
  9. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  10. Regulation of cell death by transfer RNA
  11. High-purity enzymatic synthesis of site-specifically modified tRNA
  12. Recognition of guanosine by dissimilar tRNA methyltransferases
  13. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
  14. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  15. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)
  16. A role for SUMO in nucleotide excision repair
  17. Pyrophosphorolysis of CCA addition: Implication for fidelity
  18. Allosteric communication in cysteinyl tRNA synthetase: A network of direct and indirect readout
  19. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding.
  20. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor
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