292E Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University
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Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression
  2. Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
  3. The UGG isoacceptor of tRNAPro is naturally prone to frameshifts
  4. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  5. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  6. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
  7. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  8. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  9. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  10. The selective tRNA aminoacylation mechanism based on a single G.U pair
  11. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  12. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  13. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  14. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  15. Conservation of structure and mechanism by Trm5 enzymes
  16. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  17. Regulation of cell death by transfer RNA
  18. High-purity enzymatic synthesis of site-specifically modified tRNA.
  19. Recognition of guanosine by dissimilar tRNA methyltransferases
  20. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
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