2238 Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University

Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  2. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  3. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  4. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  5. The selective tRNA aminoacylation mechanism based on a single G.U pair
  6. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  7. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  8. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  9. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  10. Conservation of structure and mechanism by Trm5 enzymes
  11. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  12. Regulation of cell death by transfer RNA
  13. High-purity enzymatic synthesis of site-specifically modified tRNA
  14. Recognition of guanosine by dissimilar tRNA methyltransferases
  15. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
  16. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  17. A recurrent 05BE loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)
  18. A role for SUMO in nucleotide excision repair
  19. Pyrophosphorolysis of CCA addition: Implication for fidelity
  20. Allosteric communication in cysteinyl tRNA synthetase: A network of direct and indirect readout