28B0 Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University

Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
  2. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  3. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  4. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
  5. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  6. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  7. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  8. The selective tRNA aminoacylation mechanism based on a single G.U pair
  9. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  10. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  11. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  12. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  13. Conservation of structure and mechanism by Trm5 enzymes
  14. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  15. Regulation of cell death by transfer RNA
  16. High-purity enzymatic synthesis of site-specifically modified tRNA.
  17. Recognition of guanosine by dissimilar tRNA methyltransferases
  18. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
  19. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  20. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)