0B68 Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University

Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys
  2. The selective tRNA aminoacylation mechanism based on a single G.U pair
  3. A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N)
  4. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  5. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  6. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  7. Conservation of structure and mechanism by Trm5 enzymes
  8. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  9. Regulation of cell death by transfer RNA
  10. High-purity enzymatic synthesis of site-specifically modified tRNA
  11. Recognition of guanosine by dissimilar tRNA methyltransferases
  12. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
  13. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  14. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)
  15. A role for SUMO in nucleotide excision repair
  16. Pyrophosphorolysis of CCA addition: Implication for fidelity
  17. Allosteric communication in cysteinyl tRNA synthetase: A network of direct and indirect readout
  18. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding.
  19. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor
  20. Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5