16D0 Hou, Ya-ming - Thomas Jefferson University - Thomas Jefferson University

Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 503-5393 fax

Most Recent Peer-reviewed Publications

  1. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  2. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  3. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  4. Conservation of structure and mechanism by Trm5 enzymes
  5. The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
  6. Regulation of cell death by transfer RNA
  7. High-purity enzymatic synthesis of site-specifically modified tRNA
  8. Recognition of guanosine by dissimilar tRNA methyltransferases
  9. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
  10. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  11. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)
  12. A role for SUMO in nucleotide excision repair
  13. Pyrophosphorolysis of CCA addition: Implication for fidelity
  14. Allosteric communication in cysteinyl tRNA synthetase: A network of direct and indirect readout
  15. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding.
  16. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor
  17. Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5
  18. Biosynthesis: A new (old) way of hijacking tRNA
  19. Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy
  20. Apoptotic regulation and tRNA