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Alexander M. Mazo, PhD

Contact Dr. Mazo

1020 Locust Street
JAH, Rm. 485
Philadelphia, PA 19107

(215) 503-4785
(215) 923-7144 fax

Most Recent Peer-reviewed Publications

  1. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification
  2. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation
  3. Detection of RNA-DNA association by a proximity ligation-based method
  4. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication
  5. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
  6. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
  7. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
  8. The Role of Epigenetic Modifications in Cancer
  9. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation
  10. Regulatory noncoding RNAs at Hox loci
  11. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
  12. Transcriptional interference: An unexpected layer of complexity in gene regulation
  13. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
  14. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos
  15. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
  16. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes
  17. ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
  18. Purification and Biochemical Properties of the Drosophila TAC1 Complex
  19. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex
  20. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila