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Alexander M. Mazo, PhD

Contact Dr. Mazo

1020 Locust Street
JAH, Rm. 485
Philadelphia, PA 19107

(215) 503-4785
(215) 923-7144 fax

Most Recent Peer-reviewed Publications

  1. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70
  2. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation
  3. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification
  4. Chromatin proteins and RNA are associated with DNA during all phases of mitosis
  5. Detection of RNA-DNA association by a proximity ligation-based method
  6. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication
  7. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
  8. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
  9. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
  10. The Role of Epigenetic Modifications in Cancer
  11. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation
  12. Regulatory noncoding RNAs at Hox loci
  13. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
  14. Transcriptional interference: An unexpected layer of complexity in gene regulation
  15. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
  16. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos
  17. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
  18. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes
  19. ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
  20. Purification and Biochemical Properties of the Drosophila TAC1 Complex