0B68 Pascal, John M. - Thomas Jefferson University - Thomas Jefferson University

John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
BLSB 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  2. The rise and fall of poly(ADP-ribose): An enzymatic perspective
  3. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
  4. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  5. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  6. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  7. Selective phosphorylation modulates the PIP 2 sensitivity of the CaM-SK channel complex
  8. Structural implications for selective targeting of PARPs
  9. Structural biology of the writers, readers, and erase 11B5 rs in mono- and poly(ADP-ribose) mediated signaling
  10. New players to the field of ADP-ribosylation make the final cut
  11. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  12. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  13. Dual roles of PARP-1 promote cancer growth and progression
  14. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  15. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  16. Structural basis for calmodulin as a dynamic calcium sensor
  17. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  18. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  19. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  20. Purification of human PARP-1 and PARP-1 domains from escherichia coli for structural and biochemical analysis