0B68 Pascal, John M. - Thomas Jefferson University - Thomas Jefferson University
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John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
BLSB 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex
  2. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  3. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  4. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  5. Structural implications for selective targeting of PARPs
  6. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  7. New players to the field of ADP-ribosylation make the final cut
  8. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  9. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  10. Dual roles of PARP-1 promote cancer growth and progression
  11. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  12. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  13. Structural basis for calmodulin as a dynamic calcium sensor
  14. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  15. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  16. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  17. Purification of human PARP-1 and PARP-1 domains from escherichia coli for structural and biochemical analysis
  18. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: Structural and functional insights into DNA-dependent PARP-1 activity
  19. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction
  20. The DNA binding domain of human DNA ligase I interacts with bo 015D th nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
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