0B68 Pascal, John M. - Thomas Jefferson University - Thomas Jefferson University
jmp007

John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
BLSB 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  2. Structural implications for selective targeting of PARPs
  3. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  4. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  5. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  6. Dual roles of PARP-1 promote cancer growth and progression
  7. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  8. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  9. Structural basis for calmodulin as a dynamic calcium sensor
  10. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
  11. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  12. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  13. Purification of human PARP-1 and PARP-1 domains from escherichia coli for structural and biochemical analysis
  14. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: Structural and functional insights into DNA-dependent PARP-1 activity
  15. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction
  16. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1
  17. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation (Journal of Biological Chemistry (2008) 283, (4105-4114))
  18. A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation
  19. DNA and RNA ligases: structural variations and shared mechanisms
  20. RNA ligase does the AMP shuffle
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