16D0 Pascal, John M. - Thomas Jefferson University - Thomas Jefferson University
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John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
BLSB 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
  2. Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1
  3. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
  4. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  5. The rise and fall of poly(ADP-ribose): An enzymatic perspective
  6. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
  7. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  8. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  9. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  10. Selective phosphorylation modulates the PIP 2 sensitivity of the CaM-SK channel complex
  11. Structural implications for selective targeting of PARPs
  12. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  13. New players to the field of ADP-ribosylation make the final cut
  14. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  15. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  16. Dual roles of PARP-1 promote cancer growth and progression
  17. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
  18. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
  19. Structural basis for calmodulin as a dynamic calcium sensor
  20. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
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