0B68 Pascal, John M. - Thomas Jefferson University - Thomas Jefferson University

John M. Pascal, PhD

Contact Dr. Pascal

233 South 10th Street
BLSB 804
Philadelphia, PA 19107

(215) 503-4596
(215) 923-2117 fax

Most Recent Peer-reviewed Publications

  1. Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification
  2. Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling
  3. A PARP1-ERK2 synergism is required for the induction of LTP
  4. Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1
  5. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
  6. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
  7. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  8. The rise and fall of poly(ADP-ribose): An enzymatic perspective
  9. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs
  10. Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors
  11. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
  12. Selective phosphorylation modulates the PIP 2 sensitivity of the CaM-SK channel complex
  13. Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer
  14. Structural implications for selective targeting of PARPs
  15. Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
  16. New players to the field of ADP-ribosylation make the final cut
  17. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
  18. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
  19. Dual roles of PARP-1 promote cancer growth and progression
  20. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels