Peter Ronner, PhD
Philadelphia, PA 19107-5541
(215) 923-9162 fax
Most Recent Peer-reviewed Publications
- Effects of glucose and amino acids on free ADP in βHC9 insulin-secreting cells
- Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP
- Perfusion of pancreatic endocrine tissue of teleost fish
- Sulfonylurea-binding sites and ATP-sensitive K+ channels in α-TC glucagonoma and β-TC insulinoma cells
- Effect of the hypoglycaemic drug (−)‐AZ‐DF‐265 on ATP‐sensitive potassium channels in rat pancreatic β‐cells
PhD, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland; Biochemistry - 1978
Expertise & Research Interests
I am interested in the education of students of medicine and pharmacy. I am particularly eager to use results of research into learning to help struggling students succeed.
I wrote the textbook Netter’s Essential Biochemistry, (2017 Elsevier). The book covers the molecular biology and metabolism that students of medicine or pharmacy need to pass their licensing exams.
Since 1995, I have directed a 'biochemistry' course for medical students. Since 2003, this course included molecular biology, cell biology, genetics, metabolism, and a bit of cell physiology. I am currently the Biochemistry Thread Director for the new JeffMD curriculum that relies heavily on case-based learning and is to be rolled out in August of 2017.
Since 2008, I have directed a biochemistry course for pharmacy students. The content of this course is shaped largely by the ACPE Standards 2016 for biochemistry and by the needs of first-year pharmacy students. I teach most of the sessions in this course.
Previously, my research had focused on the mechanisms that control the secretion of insulin and glucagon from the pancreas. Using electrophysiology, I found ATP-sensitive K+-channels (KATP channels) in rat non-beta-islet cells (prepared by flow-cytometry) that were most likely alpha-cells. I also found KATP channels in alphaTC glucagonoma cells. I observed that the sulfonylurea glyburide shows cooperativity when binding to sulfonylurea receptors (SUR), while other inhibitors of SUR do not show cooperativity. I devised a luminometric method to measure free AMP and ADP in creatine-loaded cells and used this method to study the regulation of KATP channels. In previous years, I had devised a method to perfuse the endocrine pancreas (Brockmann body, weight is ~5 mg) of channel catfish in vitro, and I characterized hormone secretion from this organ in response to various fuels. An intriguing, yet unexplained finding is that the perfused Brockmann body secretes insulin and somatostatin in response to 2-deoxyglucose.
As part of my thesis work on the Ca,Mg-ATPase of human erythrocyte membranes, I discovered that the activity of this ATPase depends on the presence of phosphatidylserine.
Adenosine diphosphate; ATP-Sensitive K+ Channel; Biochemistry; Blood Glucose; Book; Brockmann body; Creatine; Diabetes; Education; Electrophysiology; Endocrinology; Glucagon; Instruction (Medical, Pharmacy); Insulin; Luciferase; Pancreatic Islet; Perfusion; Potassium Channel; Radioimmunoassay; Somatostatin; Sulfonylurea
English, German, Swiss-German, Some French, Some Italian