pbw101

Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 South 10th Street
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. Functional selectivity of GPCR-directed drug action through location bias
  2. Dysregulated GPCR signaling and therapeutic options in uveal melanoma
  3. Inducible inhibition of Gβγ reveals localization-dependent functions at the plasma membrane and Golgi
  4. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1
  5. PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway
  6. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
  7. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function
  8. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
  9. G protein trafficking.
  10. Non-canonical signaling and localizations of heterotrimeric G proteins
  11. Reversible palmitoylation in g protein signaling
  12. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  13. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution
  14. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  15. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  16. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
  17. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  18. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  19. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
  20. Assembly and trafficking of heterotrimeric G proteins