0B68 Wedegaertner, Philip B. - Thomas Jefferson University - Thomas Jefferson University

Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 South 10th Street
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway
  2. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
  3. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function
  4. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
  5. G protein trafficking.
  6. Non-canonical signaling and localizations of heterotrimeric G proteins
  7. Reversible palmitoylation in g protein signaling
  8. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  9. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution
  10. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  11. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  12. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
  13. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  14. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  15. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
  16. Assembly and trafficking of heterotrimeric G proteins
  17. Lipid-protein interactions in GPCR-associated signaling
  18. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
  19. Loss of association between activated Gαq and Gβγ disrupts receptor-dependent and receptor-independent signaling
  20. Functional consequences of Gα13 mutations that disrupt interaction with p115RhoGEF