pbw101

Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 South 10th Street
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. Inducible inhibition of Gβγ reveals localization-dependent functions at the plasma membrane and Golgi
  2. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1
  3. PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway
  4. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway
  5. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function
  6. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
  7. G protein trafficking.
  8. Non-canonical signaling and localizations of heterotrimeric G proteins
  9. Reversible palmitoylation in g protein signaling
  10. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  11. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution
  12. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  13. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  14. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
  15. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  16. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  17. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
  18. Assembly and trafficking of heterotrimeric G proteins
  19. Lipid-protein interactions in GPCR-associated signaling
  20. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth