0B68 Wedegaertner, Philip B. - Thomas Jefferson University - Thomas Jefferson University

Philip B. Wedegaertner, PhD

Contact Dr. Wedegaertner

233 S. 10th St.
839 BLSB
Philadelphia, PA 19107

(215) 503-3137

Most Recent Peer-reviewed Publications

  1. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function
  2. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
  3. G protein trafficking.
  4. Non-canonical signaling and localizations of heterotrimeric G proteins
  5. Reversible palmitoylation in g protein signaling
  6. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
  7. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution
  8. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
  9. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
  10. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
  11. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
  12. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
  13. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
  14. Assembly and trafficking of heterotrimeric G proteins
  15. Lipid-protein interactions in GPCR-associated signaling
  16. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
  17. Loss of association between activated Gαq and Gβγ disrupts receptor-dependent and receptor-independent signaling
  18. Functional consequences of Gα13 mutations that disrupt interaction with p115RhoGEF
  19. Identification of a specific domain responsible for JNK2α2 autophosphorylation
  20. Palmitoylation and plasma membrane targeting of RGS7 are promoted by αo