2A74 Calabretta, Bruno - Thomas Jefferson University - Thomas Jefferson University
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Bruno Calabretta, MD, PhD

Contact Dr. Calabretta

Kimmel Cancer Center
233 S. Tenth Street, Suite 630 A
Philadelphia, PA 19107

(215) 503-4522

Most Recent Peer-reviewed Publications

  1. Autophagy in Chronic Myeloid Leukaemia: Stem cell survival and implication in therapy
  2. Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion
  3. The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: Correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform
  4. Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1
  5. Expression of p89 c-Mybex9b, an alternatively spliced form of c-Myb, is required for proliferation and survival of p210BCR/ABL-expressing cells
  6. Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPα in K562 cells
  7. c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells
  8. Suppression of autophagy by BCR/ABL
  9. TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER + breast cancer cells
  10. Regulation of microRNA-145 by growth arrest and differentiation
  11. Inhibition of autophagy: A new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors
  12. Expression of the transcriptional repressor Gfi-1 is regulated by C/EBPα and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells
  13. The biological effects of C/EBPα in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain
  14. Expression of slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin
  15. Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model
  16. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
  17. Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPα in p210 BCR/ABL-expressing cells
  18. Slug (SNAI2) down-regulation by interference facilitates apoptosis and inhibits invasive growth in neuroblastoma preclinical models
  19. Requirement of c-Myb for p210 BCR/ABL-dependent transformation of hematopoietic progenitors and leukemogenesis
  20. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide
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