Adam Ertel, PhD
233 S. Tenth Street, Suite 1009
Philadelphia, PA 19107
(215) 503-9142 fax
Most Recent Peer-reviewed Publications
- The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness
- Retinoblastoma protein potentiates the innate immune response in hepatocytes: Significance for hepatocellular carcinoma
- The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer
- Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation
- Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint
PhD, Biomedical Engineering/Bioinformatics, Drexel University, Philadelphia, PA - 2008
BS, Electrical Engineering, University of Connecticut , CT
Expertise & Research Interests
Bioinformatics and pathway-based approaches to gene expression profiling.
Gene interactions and molecular profiles in cancer.
SNP genotype and copy number analysis for genome-wide association studies.
My research focuses on patterns of gene expression, gene regulation, and gene product interactions that can be inferred from large collections of mRNA expression data. This approach is useful for identifying normal interaction and regulatory connections between genes as well as the disruption of these connections in complex diseases such as cancer. Bioinformatics approaches allow these connections to be easily extended into the context of biological pathways in order to understand global changes with respect to disease states or treatment. I’ve collaborated extensively with other Principal Investigators in the KCC to establish automated analysis pipelines for genes, gene signatures, and interaction profiles that provide informative readouts of pathway function and dysfunction associated with disease states.
Future plans include the automation of a publically accessible web-based tool that provides a user-friendly readout of genes, gene signatures, and interaction profiles across multiple phenotypes, disease states, and therapeutic interventions. As this tool evolves, it will be useful for designing and implementing classification algorithms to assist disease diagnosis and guided therapy.