Karen E. Knudsen, PhD

Contact Dr. Knudsen

Sidney Kimmel Cancer Center
233 South 10th Street
BLSB 1050
Philadelphia, PA 19107

(215) 503-5692

Most Recent Peer-reviewed Publications

  1. Analysis of circulating cell-free DnA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors
  2. Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
  3. PARP Inhibitors in Prostate Cancer
  4. Sigma1 targeting to suppress aberrant androgen receptor signaling in prostate cancer
  5. Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle
  6. Cell cycle-coupled expansion of AR activity promotes cancer progression
  7. Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report
  8. There and back again: The middle earth of DNA repair
  9. Linking DNA Damage and Hormone Signaling Pathways in Cancer
  10. Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for high-risk prostate cancer
  11. Downregulation of critical oncogenes by the selective SK2 Inhibitor ABC294640 hinders prostate cancer progression
  12. Development and Validation of a Scalable Next-Generation Sequencing System for Assessing Relevant Somatic Variants in Solid Tumors
  13. Novel actions of next-generation taxanes benefit advanced stages of prostate cancer
  14. Models of neuroendocrine prostate cancer
  15. Cell-cycle-dependent regulation of androgen receptor function
  16. Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
  17. Consequence of the tumor-associated conversion to cyclin D1b
  18. Hormone whodunit: Clues for solving the case of intratumor androgen production
  19. The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness
  20. Genomic prostate cancer classifier predicts biochemical failure and metastases in patients after postoperative radiation therapy