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Lucia Languino, PhD

Contact Dr. Languino

Sidney Kimmel Cancer Center
233 S. Tenth Street, Suite 506
Philadelphia, PA 19107

(215) 503-3442

Most Recent Peer-reviewed Publications

  1. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
  2. A neuronal network of mitochondrial dynamics regulates metastasis
  3. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development
  4. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  5. αvβ6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor
  6. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  7. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
  8. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1
  9. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer
  10. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
  11. Deregulation of MIR-34b/Sox2 predicts prostate cancer progression
  12. αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression
  13. The α<inf>v</inf>β<inf>6</inf> integrin is transferred intercellularly via exosomes
  14. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion
  15. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
  16. Adaptive mitochondrial reprogramming and resistance to PI3K therapy
  17. Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks
  18. Integrin avb6 Promotes an osteolytic program in cancer cells by upregulating MMP2
  19. IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels
  20. Landscape of the mitochondrial Hsp90 metabolome in tumours