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Lucia Languino, PhD

Contact Dr. Languino

Sidney Kimmel Cancer Center
233 S. Tenth Street, Suite 506
Philadelphia, PA 19107

(215) 503-3442

Most Recent Peer-reviewed Publications

  1. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development
  2. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  3. αvβ6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor
  4. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  5. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
  6. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1
  7. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
  8. Deregulation of MIR-34b/Sox2 predicts prostate cancer progression
  9. αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression
  10. The α<inf>v</inf>β<inf>6</inf> integrin is transferred intercellularly via exosomes
  11. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion
  12. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
  13. Adaptive mitochondrial reprogramming and resistance to PI3K therapy
  14. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer
  15. Integrin avb6 Promotes an osteolytic program in cancer cells by upregulating MMP2
  16. Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks
  17. IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels
  18. Landscape of the mitochondrial Hsp90 metabolome in tumours
  19. β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
  20. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells