0B68 Languino, Lucia - Thomas Jefferson University - Thomas Jefferson University

Lucia Languino, PhD

Contact Dr. Languino

Kimmel Cancer Center
233 S. Tenth Street, Suite 506
Philadelphia, PA 19107

(215) 503-3442

Most Recent Peer-reviewed Publications

  1. Integrin avb6 Promotes an osteolytic program in cancer cells by upregulating MMP2
  2. Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks
  3. IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels
  4. Landscape of the mitochondrial Hsp90 metabolome in tumours
  5. β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
  6. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
  7. Trop-2 promotes prostate cancer metastasis by modulating β1 integrin functions
  8. Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis
  9. Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s
  10. PSA regulates androgen receptor expression in prostate cancer cells
  11. α vβ 6 integrin expression is induced in the POET and Pten pc-/- mouse models of prostatic inflammation and prostatic adenocarcinoma
  12. TRAP-1, the mitochondrial Hsp90
  13. Insulin-like growth factor 1 stimulation of androgen receptor activity requires β 1A integrins
  14. Molecular targets for radiation oncology in prostate cancer
  15. The search for a better prostate cancer biomarker
  16. Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
  17. Preclinical characterization of mitochondria-targeted small molecule Hsp90 inhibitors, gamitrinibs, in advanced prostate cancer
  18. β1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1
  19. CD133, Trop-2 and α2β1 integrin surface receptors as markers of putative human prostate cancer stem cells
  20. The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFβ in prostate cancer cells