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Sarmistha Mukherjee, PhD

Contact Dr. Mukherjee

Kimmel Cancer Center
233 S. Tenth Street, Suite 519
Philadelphia, PA 19107

(215) 503-6281

Publications for this author are currently unavailable.

Education
PhD, Biochemistry, University of Calcutta, India

Expertise & Research Interests

Currently I am investigating the role of PGC-1α, a transcriptional coactivator and master regulator of energy metabolism, during liver regeneration. To fully understand the transcriptional regulation of liver growth, proliferation and metabolic homeostasis, we are using genetically modified Ppargc1a floxed mutant mice in which PGC1a can be conditionally deleted in hepatocytes in vivo.

I am also working to validate microRNA targets important in liver regeneration. We have identified and validated microRNA regulatory elements (MREs ) in a group of biologically relevant mRNAs associated with cell proliferation by using a novel prediction algorithm that incorporates miRNA recruitment to the RISC and predicted MREs within Argonaute footprints.

To identify and validate novel targets of microRNAs that are crucial in the functions of liver regeneration, growth and repair and also in hepatocellular carcinomas. These discoveries may lead to development of novel microRNA based therapeutic strategies for hepatocellular carcinomas.

 Current Research Project: NIH R01 DK/CA56669 (PI-Greenbaum). Transcriptional Control in Hepatocyte Proliferation

Keywords

Liver regeneration, coactivators, nuclear hormone receptors, microRNA