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Hallgeir Rui, MD, PhD

Contact Dr. Rui

Sidney Kimmel Cancer Center
233 South Tenth Street,
Suite 332
Philadelphia, PA 19107

(215) 503-9259
(215) 503-9246 fax

Education

MD, University of Oslo, Norway - 1980-1987
PhD, Pathology, University of Oslo, Norway - 1983-1988

Expertise & Research Interests

Dr. Rui has made a series of contributions to increased understanding of the molecular mechanisms of signal transduction by cytokine receptors and hormones. Dr. Rui was the first to isolate a prolactin receptor-associated tyrosine kinase, and to identify this molecule as Janus kinase-2. Dr. Rui's laboratory has maintained a focus on cytokine and hormone receptor function with a primary goal of understanding the role of downstream Jak-Stat pathways and their aberrations in breast cancer.

Activation of Stat5 is a strong favorable prognostic marker in breast cancer and an invasion-suppressive role of Stat5 in human breast cancer may represent a biological mechanism. Loss of Stat5 in estrogen-receptor-positive breast cancer is associated with increased risk of antiestrogen resistance. Dr. Rui and his team have invented and patented cutting-edge matrix assembly technology for generation of high density tumor tissue arrays for high-through-put molecular profiling. Dr. Rui is the PI of a $6.7 million, 5 year Komen Promise Grant to a consortium of multidisciplinary investigators to classify malignant breast tumors based on quantitative expression of druggable target proteins for improved personalized cancer care. Advanced quantitative immunofluorescence-based histocytometry technologies are being used. This consortium project also involves a novel Bayesian adaptive biomarker-centered Phase II clinical trial of a Parp-inhibitor in the neoadjuvant setting for triple-negative breast cancer.

Keywords

cancer; breast cancer; cytokine receptors, hormone; endocrinology; prolactin; growth hormone; estrogen; glucocorticoid; steroid hormones; Jak2; Stat5; Stat5a; Stat5b; immunohistochemistry; pathology; biomarker; early detection; microarray; tissue microarray; mouse modeling; EGFR; Her2; ErbB2; prolactin receptor