Sonsoles Piera-Velazquez, PhD
Bluemle Life Sciences Building, Suite 422
Philadelphia, PA 19107
Most Recent Peer-reviewed Publications
- Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts
- Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis
- Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of Systemic Sclerosis and Sjögren's Syndrome
- Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases
- Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts
PhD Biochemistry. University of Alicante (Spain) - 1996
Postdoctoral Fellowship. Division of Rheumatology, Thomas Jefferson University 1999-2001.
Arthritis Foundation Fellowship. Division of Rheumatology, Thomas Jefferson University. 2001-2004.
Expertise and Research Interests
Study of the molecular events involved in the development of articular cartilage damage in human osteoarthritis with special emphasis on alterations in chondrocyte gene expression induced by cytokines and other inflammatory mediators.
Study of the mechanisms of chondrocyte phenotype stability and of its loss during de-differentiation focusing on the role of telomerase expression, NOX4 and oxygen radicals and activation of the Wnt pathway.
Recent studies on the alterations of expression of extracellular matrix genes in the novel fibrotic disease, Nephrogenic Systemic Fibrosis, and on the role of exposure to Gadolinium (Gd) containing magnetic resonance contrast agents in its pathogenesis.
Osteoarthritis, cartilage, chondrocyte phenotype and regulation of gene expression, telomerase, SOX9 promoter, Nephrogenic Systemic Fibrosis.