0B68 Martinez-Outshoorn, Ubaldo - Thomas Jefferson University - Thomas Jefferson University
Dr. Martinez-Outshoorn

Ubaldo Martinez-Outshoorn, MD

Contact Dr. Martinez-Outshoorn

925 Chestnut Street
Suite 220A
Philadelphia, PA 19107

(215) 955-8874

Most Recent Peer-reviewed Publications

  1. JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention
  2. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
  3. Tumor microenvironment: Introduction
  4. Tumor microenvironment and metabolic synergy in breast cancers: Critical importance of mitochondrial fuels and function
  5. Cancer metabolism: New validated targets for drug discovery
  6. Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer
  7. Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery
  8. Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment RAS and NFκB target stromal MCT4
  9. Reverse warburg effect in a patient with aggressive B-cell lymphoma: Is lactic acidosis a paraneoplastic syndrome?
  10. Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis
  11. Cancer metabolism, stemness and tumor recurrence : MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer
  12. Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment
  13. Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism Implications for breast cancer prevention
  14. Creating a tumor-resistant microenvironment Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo
  15. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: Understanding chemoprevention with metformin
  16. Mitochondria "fuel" breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells
  17. Genetic induction of the Warburg effect inhibits tumor growth
  18. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: Implications for breast cancer prevention with antioxidant therapies
  19. Hereditary ovarian cancer and two-compartment tumor metabolism: Epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma
  20. Ketone body utilization drives tumor growth and metastasis
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