Satish C. Rattan, DVM
College Building, Room 901
Philadelphia, PA 19107
(215) 955-5553 fax
Most Recent Peer-reviewed Publications
- Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation
- Heme oxygenase-1 upregulation modulates tone and fibroelastic properties of internal anal sphincter.
- Smooth muscle-specific myosin phosphatase target subunit 1 (MYPT1): An important piece of the puzzle
- Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer
- Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle
DVM, Punjab Agricultural University, Hissar, India - 1968
MS, Pharmacology, University of Houston, TX - 1970
Baylor College of Medicine, Houston, TX University of Texas, South Western Medical School, Dallas, TX
Professor, Medicine, Thomas Jefferson Univ., Philadelphia, PA, 1989- current
Associate Professor, Harvard Medical School, Boston, MA, 1988-89
Assistant Professor, Harvard Medical School, Boston, MA, 1981-87
Assistant Professor, University of Texas Health Science Center, San Antonio, TX, 1978-81
Honors & Awards
Council of Indian Organizations Award for Professors & Acadamic Excellence, 2006
Janssen Award, for Basic Research in Gastroenterology, 1997
Merit Scholarship, Punjab Agricultural University, Hissar, India, 1964-68
Journal of Pharmacology & Experimental Therapeutics, 1992-99
American Journal of Physiology, 2010-
American Journal of Physiology, 1992-98
Associate Editor GASTROENTEROLOGY, 1986-89
Other Experience & Professional Experience
Teaching Physiology/Pharmacology to Medical Students, 1978-2002
Chief Org. and Director of Am. Motility Society Meeting, Philadelphia, PA, 1998
Member Appoint. and Promot. Committee, Thomas Jefferson University, 2000-
Member Inst. Animal Care & Use Committee, Thomas Jefferson University, 2004-
Member, NIH Study Section, 2003
Expertise & Research Interests
Dr. Rattan is internationally recognized as an outstanding educator and researcher. He is frequently invited as a visiting Professor. Dr. Rattan has received multiple National and International awards in research and teaching.
In 1997, he received a prestigious Janssen Award for his outstanding basic research in Gastroenterology.
In 2006, he was honored by the Council of Indian Organizations as an outstanding professional.
Dr. Rattan''s research has been continuously funded by the National Institutes of Health.
He has been an Associate Editor of GASTROENTEROLOGY, on editorial board of, and a reviewer for a number of prestigious journals.
Research Interest: Disorders of the internal anal sphincter (IAS) underlie many clinical abnormalities, such as fecal incontinence and constipation, hemorrhoids and anal fissures. Such disorders are of particular importance in the growing population of the elderly. The focus of Dr. Rattan''s research has been on: 1. the nature and role of inhibitory neurotransmitters and mediators; 2. the neural pathways in the rectoanal inhibitory reflex; and 3. the molecular bases underlying myogenic tone in the IAS. Using IAS as the model of tonic smooth muscles, Dr. Rattan''s basic studies have provided major advances in the field of of molecular biology of the smooth muscle. The concepts learnt from his studies are directly applicable in a number of organs in the body. Dr. Rattan''s sudies provide important information on the pathophysiology and therapeutic development of anorectal disorders.
Gastrointestinal Motility Disorders; Internal Anal Sphincter; Neurohumoral Control; Immunocytochemistry; Confocal Microscopy; Nonadrenergic Noncholinergic Neurons; Smooth Muscle Tone and Relaxation; Nitric Oxide; Nitric Oxide Synthase; Carbon Monoxide; Heme Oxygenase; Protein Kinase C; RhoA/Rho Kinase; Receptor Binding; Tissue Cell Culture; Renin-Angiotensin-System; Prostanoids