Thomas Jefferson UniversitySidney Kimmel Medical College

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Hepatitis C Center

It is estimated that 3.2 million Americans are infected with Hepatitis C virus, the majority infected with genotype 1.  Of these, less than half are aware of their diagnosis, and fewer are treated.  We are at the dawn of a new era in Hepatitis C treatment, with the first new medications in 10 years approved by the Federal Drug Administration (FDA) in the spring of 2011, and 2 more medications approved in December 2013.  With these approvals comes a significantly increased anticipated volume of patients who will seek or be recommended to undergo treatment with anti-viral medications including protease inhibitors, polymerase inhibitors, ribavirin, and/or pegylated interferon.  While efficacy of treatment has risen, so too has the complexity of treating Hepatitis C.  The Jefferson Hepatitis C Center, created in 2011 under the direction of Jonathan Fenkel, MD, aims to provide a coordinated approach to the delivery of care to patients with Hepatitis C and patients with coinfection of Hepatitis C and Hepatitis B and/or HIV.  

Center Highlights

  • Outpatient Hepatitis C treatment clinic
  • Active clinical trials program
  • Expert liver pathologists, subspecialists, and radiologists
  • Co-management opportunities for community physicians – tailored program to meet individual provider and patient needs
  • Expert Consultations including detailed plan highlighting potential drug interactions and treatment considerations.
Jonathan Fenkel








Jonathan M. Fenkel, MD
Director, Jefferson Hepatitis C Center

Contact Information:
Jonathan Fenkel, MD
Director, Jefferson Hepatitis C Center
132 S. 10th Street
Suite 480, Main Building
Philadelphia, PA 19107
(215) 955-8900

Brandy Rich, MA
Clinical Coordinator
Jefferson Hepatitis C Center
(215) 955-8900

Steering Committee

Jonathan Fenkel, MD (Chair) - Gastroenterology & Hepatology
Ashlie Burkart, MD – Pathology, Anatomy and Cell Biology
Doris Chan, CRNP – Gastroenterology & Hepatology
Flavius Guglielmo, MD – Radiology
Steven Herrine, MD – Gastroenterology & Hepatology
Cythia Miller, RN – Clinical Research Coordinator, Gastroenterology & Hepatology
Srikanth Nagalla, MD - Hematology
Kathleen Squires, MD – Infectious Diseases & Environmental Medicine
Robert Winn, MD – Family & Community Medicine