16D0 Holinstat, Michael - Thomas Jefferson University - Thomas Jefferson University

Michael Holinstat, PhD

Contact Dr. Holinstat

1020 Locust Street
Suite 394
Philadelphia, PA 19107

(215) 955-6121
(215) 955-9170 fax

Most Recent Peer-reviewed Publications

  1. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
  2. Racial differences in resistance to P2Y12receptor antagonists in type 2 diabetic subjects
  3. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  4. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  5. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
  6. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  7. The emerging role of oxylipins in thrombosis and diabetes
  8. 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
  9. MicroRNAs in platelet production and activation< 125C /li>
  10. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
  11. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation
  12. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
  13. Rap1-Rac1 circuits potentiate platelet activation
  14. We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs
  15. Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca 2+ entry in endothelial cells (Journal of Biological Chemistry (2004) 279, (20941-20949))
  16. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase
  17. 12-lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics
  18. Protease-activated receptor signaling in platelets activates cytosolic phospholipase a2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
  19. Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers
  20. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates