05B4 Holinstat, Michael - Thomas Jefferson University - Thomas Jefferson University

Michael Holinstat, PhD

Contact Dr. Holinstat

1020 Locust Street
Suite 394
Philadelphia, PA 19107

(215) 955-6121
(215) 955-9170 fax

Most Recent Peer-reviewed Publications

  1. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
  2. Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation
  3. Racial differences in resistance to P2Y12receptor antagonists in type 2 diabetic subjects
  4. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression
  5. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics
  6. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
  7. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis
  8. The emerging role of oxylipins in thrombosis and diabetes
  9. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  10. 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
  11. MicroRNAs in platelet production and activation
  12. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
  13. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation
  14. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
  15. Rap1-Rac1 circuits potentiate platelet activation
  16. We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs
  17. Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca 2+ entry in endothelial cells (Journal of Biological Chemistry (2004) 279, (20941-20949))
  18. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase
  19. 12-lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics
  20. Protease-activated receptor signaling in platelets activates cytosolic phospholipase a2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis