0B68 Holinstat, Michael - Thomas Jefferson University - Thomas Jefferson University
mah010

Michael Holinstat, PhD

Contact Dr. Holinstat

1015 Walnut Street
Suite 320
Philadelphia, PA 19107

(215) 955-6121
(215) 955-9170 fax

Most Recent Peer-reviewed Publications

  1. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
  2. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
  3. The emerging role of oxylipins in thrombosis and diabetes
  4. 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
  5. MicroRNAs in platelet production and activation
  6. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation
  7. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation
  8. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation
  9. Rap1-Rac1 circuits potentiate platelet activation
  10. We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs
  11. Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca 2+ entry in endothelial cells (Journal of Biological Chemistry (2004) 279, (20941-20949))
  12. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase
  13. 12-lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics
  14. Protease-activated receptor signaling in platelets activates cytosolic phospholipase a2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis
  15. Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers
  16. Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates
  17. Erratum: Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway (Molecular Pharmacology (2007) 71 (686-694))
  18. PAR1, but not PAR4, activates human platelets through a G i/o/phosphoinositide-3 kinase signaling axis
  19. Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway
  20. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
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