Ludovic Gomez, PhD
Philadelphia, PA 19107
(215) 955-1690 fax
Most Recent Peer-reviewed Publications
- Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury
- Opposite and tissue-specific effects of coenzyme Q 2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I
- Postconditioning modulates ischemia-damaged mitochondria during reperfusion
- Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion
- A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection
PhD Claude Bernard Lyon1 University, France 2006
PhD Claude Bernard Lyon1 University, France
Assistant Professor at INSERM (2012)
Visiting Assistant Professor at TJU (2013)
Research and Clinical Interests
Coronary heart disease is the leading cause of death in western countries. Myocardial infarction is a disabling disease, with infarct size being a major determinant of mortality after this common acute coronary event. Myocardial conditioning is an endogenous cardioprotective phenomenon that profoundly limits infarct size in experimental models. Currently, our challenge is to understand protection mechanisms and to translate this paradigm from the laboratory to the clinic, with the ultimate aim of limiting the burden of ischemic heart disease and potentially providing protection for other organs at risk of reperfusion injury, such as brain and kidney.
Key words: Permeability transition pore; calcium signaling; calcium mobilization from sarco/endoplasmic reticulum to mitochondria; cell death and cardioprotection.