05B4 Chan, Tung - Thomas Jefferson University - Thomas Jefferson University
Tung Chan

Tung Chan, PhD

Contact Dr. Chan

1025 Walnut Street
Suite 412
Philadelphia, PA 19107

(215) 955-4231
(215) 503-4741 fax

Most Recent Peer-reviewed Publications

  1. A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity
  2. Coordinated regulation of cardiac Na+/Ca2+ exchanger and Na+-K+-ATPase by phospholemman (FXYD1)
  3. Induced overexpression of Na+/Ca2+ exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction
  4. Cardioprotection of controlled and cardiac-specific over-expression of a2A-adenosine receptor in the pressure overload
  5. Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: Potential involvement of Na +/Ca 2+ exchanger
  6. Autoregulation of kinase dephosphorylation by ATP binding to AGC protein kinases
  7. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity
  8. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density
  9. Adenosine receptor subtypes and the heart failure phenotype: translating lessons from mice to man.
  10. Residues 248-252 and 300-304 of the cardiac naspi +/Ca 2+ exchanger are involved in its regulation by phospholemman
  11. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Ga q-mediated cell signaling
  12. The interplay between NF-kappab and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells
  13. Regulation of in vivo cardiac contractility by phospholemman: Role of Na+/Ca2+ exchange
  14. Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3
  15. The p65 subunit of NF-B binds to PGC-1, linking inflammation and metabolic disturbances in cardiac cells
  16. Phospholemman: A novel cardiac stress protein
  17. Effects of cardiac-restricted overexpression of the A2A adenosine receptor on adriamycin-induced cardiotoxicity
  18. Phospholemman and β-adrenergic stimulation in the heart
  19. Induced overexpression of Na+/Ca2+ exchanger transgene: Altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration
  20. TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model
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