Jin O-Uchi, MD, PhD
Philadelphia, PA 19107
(215) 503-5731 fax
Most Recent Peer-reviewed Publications
- Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter
- Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling
- Molecular and functional identification of a mitochondrial ryanodine receptor in neurons
- Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum
- Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts
The Jikei University School of Medicine, Tokyo Japan - 2001
Jikei University Hospital, Tokyo, Japan, 2001-2003
Postdoctoral Research associate, The Jikei University School of Medicine, Tokyo, Japan, 2006-2008 Postdoctoral Research associate, University of Rochester School of Medicine and Dentistry, Rochester NY, 2008-2011
Medical Practitioner, National Medical Board in Japan, 2001
Medical License, Kanagawa Prefecture, Japan, 2001
Research and Clinical Interests
My research interest is to understand the detail mechanism underlying the cardiac excitation and contraction/metabolism coupling by Ca2+ ion in the physiological and pathological conditions. I have a broad background in cardiac electrophysiology, with specific training and expertise. I am mainly investigating the significance of adrenergic signaling in heart and its regulation of cardiac ion channel/transporters using cardiac muscle cells.
My previous works were focusing on the regulation of cardiac ion channel/transporter by downstream kinases of adrenergic receptors especially PKA (Biochem Biophys Res Commun.2009, Circulation 2012), PKC, PKD (Circ Res 2012) and CaMKII (Proc Natl Acad Sci. USA, 2005, Circ Res, 2008, Am J Physiol Heart Circ Physiol. 2010). In addition, to acquire updated clinical information, I collaborated with clinical cardiologists in University of Rochester and investigated the risk stratification and therapy management for Long QT syndrome patients focusing on adrenergic modification of mutant human channels (Science Translational Medicine, 2011, Circulation 2012).
My current project is to determine the mitochondrial Ca2+ handling mechanisms in cardiac muscle cells under the guidance of Prof. Shey-Shing Sheu. Especially, I am interested in the functional modification of Ca2+ ion channel/transporters participating in mitochondrial Ca2+ influx mechanism by cardiac signaling in the physiological and pathological conditions.