Shi Pan

Shi Pan, PhD

Contact Dr. Pan

1020 Locust Street
Suite 543G
Philadelphia, PA 19107

(215) 503-4264
(215) 503-5731 fax

Medical School

University of Tokyo - 1998

Degree

Ph.D. Molecular and Cellular Biology, University of Tokyo 1998

University Appointment

Research Assistant Professor

Research and Clinical Interests

Dr. Pan is interested in the redox-sensitive molecular mechanisms in cardiovascular diseases. One of her research interests is the role of redox molecules in the modulation of protein function and cell signaling. Her studies have demonstrated for the first time that caspase-3 is modified by S-glutathiolation, a redox-sensitive posttranslational modification. More importantly, this modification plays a key regulatory role in caspase-3 cleavage and cell death. Her studies on glucose 6-phosphate dehydrogenase, the key enzyme of pentose phosphate pathway producing NADPH, have found that this enzyme is regulated by Src-mediated tyrosine phosphorylation, and this phosphorylation is crucial in VEGF-mediated cellular events. Currently she studies the regulation of mitochondria function in physiological and pathological settings because mitochondria are the key-determinants of cellular redox, energy metabolism and cell fate. Particularly, she is interested in the molecular mechanisms by which cellular redox and signaling regulate mitochondrial ROS generation, calcium uptake and permeability. She hopes these studies will provide insight into the role of mitochondria in cardiac muscle cells and help develop therapeutic strategies for the treatment of heart diseases.