Ross Summer, MD
Philadelphia, PA 19107
(215) 955-0830 fax
Most Recent Peer-reviewed Publications
- Plasma adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome
- Pleiotropic effects of cavin-1 deficiency on lipid metabolism
- Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
- Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions
- Scleroderma-related lung disease: Are Adipokines Involved Pathogenically?
Louisiana State University, New Orleans, LA
Johns Hopkins University
Boston University School of Medicine
Critical Care Medicine
Associate Professor of Medicine
Acute lung injury
Interstitial lung disease
General Pulmonary Medicine
The major focus of Dr Summer's laboratory is on understanding the molecular interaction between lung and adipose tissue. It is now increasingly apparent that adipose tissue is not only a storage depot for fuel but also is an important endocrine organ. Endocrine activities of adipose tissue are mediated by hormones called adipokines, which act on distant tissues to regulate diverse biological processes. Recent work from Dr Summer's laboratory and that of others has identified key roles for adipokines in regulation of immune, vascular and smooth muscle homeostasis in the lung. Using genetic and diet-induced models to alter adipose tissue function, Dr. Summer's laboratory is hoping to better elucidate the role of these newly recognized hormones in lung health and disease.
Dr Summer is also involved in several clinical projects including investigations examining the impact of physician work targets on the performance of clinical (e.g. time at bedside, number of procedures) and non-clinical (e.g. teaching, research) activities as well as investigations into the factors contributing to diagnostic delays in patients with sepsis.