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Kishore Alugupalli, PhD

Contact Dr. Alugupalli

233 South Tenth Street
Bluemle Life Sciences Building, Room 726
Philadelphia, PA 19107

(215) 503-4554
(215) 503-4153 fax

Education

BSc, Biology & Chemistry, Osmania University, Hyderabad, India
PhD, Lund University, Sweden - 1996

Fellowships

University of Massachusetts Medical School, Microbial pathogenesi

Expertise and Research Interests

B1b lymphocytes in T cell-independent memory:

Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases. A hallmark of the adaptive immune system is the generation of B cell memory, which provides a long-lasting protective antibody response that is central to the concept of vaccination. Studies from our laboratory revealed a distinct function for B1b lymphocytes, a minor subset of mature B cells that closely resembles that of memory B cells in a number of aspects. In contrast to the development of conventional B cell memory, which requires the formation of germinal centers and T cells, the development of B1b cell-mediated long-lasting antibody responses occurs independent of T cell help. T cell-independent (TI) antigens are important virulence factors expressed by a number of bacterial pathogens, including those associated with biological threats. TI antigens cannot be processed and presented to T cells and therefore are known to possess restricted T cell-dependent (TD) immunogenicity. Nevertheless, specific recognition of TI antigens by B1b cells and the highly protective antibody responses mounted by them clearly indicate a crucial role for this subset of B cells. Understanding the mechanisms of long-term immunity conferred by B1b cells are among the major interests of my laboratory.