27EC Sykulev, Yuri K. - Thomas Jefferson University - Thomas Jefferson University

Yuri K. Sykulev, MD, PhD

Contact Dr. Sykulev

233 South Tenth Street
Bluemle Life Sciences Building, Room 706
Philadelphia, PA 19107

(215) 503-4530
(215) 923-4153 fax

Most Recent Peer-reviewed Publications

  1. Integrins influence the size and dynamics of signaling microclusters in a Pyk2-dependent manner
  2. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity
  3. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
  4. Enteric alpha defensins in norm and pathology.
  5. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
  6. Enteric alpha defensins in norm and pathology
  7. Role of the MTOC in T cell effector functions
  8. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
  9. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
  10. T cell receptor signaling kinetics takes the stage
  11. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
  12. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
  13. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
  14. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
  15. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
  16. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
  17. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
  18. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response
  19. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes
  20. Target Cell Contributions to Cytotoxic T Cell Sensitivity