Timothy L. Manser, PhD

Timothy L. Manser, PhD

Contact Dr. Manser

233 South Tenth Street
Bluemle Life Sciences Building, Room 302
Philadelphia, PA 19107

(215) 503-4672
(215) 923-7145 fax

Education

BA, Biology, University of California, San Diego - 1977
PhD, Biology, University of Utah, Salt Lake City, UT - 1982

Fellowship

Massachusetts Institute of Technology, Department of Biology, Cambridge, MA

Expertise and Research Interests

My laboratory’s main research interests have been to elucidate the molecular and cellular basis for immune memory and tolerance in the B lymphocyte compartment.  My laboratory has extensive utilized mouse model systems and mouse reversed genetics approaches to address such questions for over 30 years.  In the last 20 years we have concentrated on the role of the germinal center (GC) in the antigen receptor diversification and selection events that culminate in the development of the memory B cell compartment and peripheral B cell tolerance.  Through the extensive use of mouse reversed genetics and adoptive transfer approaches, we have tested the relevance of expression of a variety of immunoregulatory factors in the formation and maintenance of the GC reaction, as well as the B cell selection events that take place in this microenvironment.

In the more recent years my laboratory has been exploiting the use of hematopoietically humanized (or human immune system – HIS) mice to help translate the lessons we have learned from studies such as those described above in mice to eventual application for the prevention, diagnosis and treatment of human disease.  We now have established a strong track record in this subfield, and are collaborating with several laboratories at Jefferson on the use of HIS mice to study the human immune response to infectious pathogens and tumors with the long-term goal of developing more effective vaccination and other therapeutic approaches for treatment and prevention of these diseases.  These collaborations include those with Dr. Kishore Alugupalli (human immune response to spirochete and encapsulated bacteria), Dr. Matthias Schnell (human immune response to newly emergent viral pathogens); Dr. David Abraham (human immune response to parasites); and Dr. Andrew Aplin (human immune response to melanoma).  We are also developing improved HIS mouse experimental platforms in which these mice express human cytokines known to augment human lymphocyte development and function.