James P. McGettigan, PhD

James P. McGettigan, PhD

Contact Dr. McGettigan

1020 Locust Street
Jefferson Alumni Hall
Room 466
Philadelphia, PA 19107

(215) 503-4629
(215) 923-7144 fax

Education

BS, Biology,  Pennsylvania State University,
State College, PA - 1986
PhD, Microbiology and Molecular Virology,
Thomas Jefferson University, Philadelphia, PA - 2002

Research & Clinical Interest

Vaccines against global health threats.  Almost 27 million people worldwide do not receive vaccines that are available and needed. Due to cost, complicated vaccine strategies and lack of availability, over two million deaths occur annually for otherwise vaccine-preventable diseases. Most of these deaths occur in developing countries, where it is clear that novel vaccines are needed. In addition, simple and less expensive vaccination strategies are also desirable for industrialized countries, where health care costs are becoming a major burden on the medical infrastructure. It is our goal to create a new class of vaccines that are simple to administer, inexpensive and effective for use in both industrialized and developing countries. To achieve this goal, our laboratory is identifying new vaccine platforms and molecular adjuvants for use against diseases that affect human health globally, most notably HIV and rabies.  

Viral vaccine immunology. To support our vaccine research, we investigate the link between host innate immunity and B cell activation against viral pathogens. We also investigate the role for alternative antibody effector functions in vaccine design. We translate these findings into new vaccines based on live replication-deficient vectors, inactivated virus particles and virus-like particles.