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Luis Sigal, DVM, PhD

Contact Dr. Sigal

333 Cottman Avenue
Room 364
Philadelphia, PA 19107

(215) 728-7061

Most Recent Peer-reviewed Publications

  1. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
  2. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
  3. The Pathogenesis and Immunobiology of Mousepox
  4. Protective CD8+ T cell memory without help
  5. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
  6. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
  7. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
  8. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses
  9. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  10. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  11. Immunology: Memory cells sound the alarm
  12. Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  13. Getting in front and behind the enemy lines to counter virus infection
  14. Memory CD8<sup>+</sup> T cell protection
  15. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
  16. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
  17. Perforin-dependent CD4 + T-cell cytotoxicity contributes to control a murine poxvirus infection
  18. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
  19. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8 + T cell response
  20. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease