27EC Sigal, Luis - Thomas Jefferson University - Thomas Jefferson University
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Luis Sigal, DVM, PhD

Contact Dr. Sigal

333 Cottman Avenue
Room 364
Philadelphia, PA 19107

(215) 728-7061

Most Recent Peer-reviewed Publications

  1. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  2. Memory CD8+ T cell protection
  3. Memory CD8+ T cell protection.
  4. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  5. Immunology: Memory cells sound the alarm
  6. Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  7. Getting in front and behind the enemy lines to counter virus infection
  8. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
  9. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
  10. Perforin-dependent CD4 + T-cell cytotoxicity contributes to control a murine poxvirus infection
  11. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
  12. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8 + T cell response
  13. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
  14. Development and function of CD94-deficient natural killer cells
  15. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
  16. Studying NK cell responses to ectromelia virus infections in mice.
  17. Direct presentation is sufficient for an efficient anti-viral CD8 + T cell response
  18. The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation
  19. Enhanced NK-cell development and function in BCAP-deficient mice
  20. The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
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