2912 Sigal, Luis - Thomas Jefferson University - Thomas Jefferson University

Luis Sigal, DVM, PhD

Contact Dr. Sigal

333 Cottman Avenue
Room 364
Philadelphia, PA 19107

(215) 728-7061

Most Recent Peer-reviewed Publications

  1. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
  2. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
  3. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses
  4. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  5. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  6. Immunology: Memory cells sound the alarm
  7. Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  8. Getting in front and behind the enemy lines to counter virus infection
  9. Memory CD8+ T cell protection
  10. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
  11. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
  12. Perforin-dependent CD4 + T-cell cytotoxicity contributes to control a murine poxvirus infection
  13. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
  14. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8 + T cell response
  15. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
  16. Development and function of CD94-deficient natural killer cells
  17. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
  18. Studying NK cell responses to ectromelia virus infections in mice.
  19. Direct presentation is sufficient for an efficient anti-viral CD8 + T cell response
  20. The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation