2815 Sykulev, Yuri - Thomas Jefferson University - Thomas Jefferson University
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Yuri Sykulev, MD, PhD

Contact Dr. Sykulev

233 S. 10th Street
Room 706
Philadelphia, PA 19107

(215) 503-4530

Most Recent Peer-reviewed Publications

  1. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
  2. Enteric alpha defensins in norm and pathology.
  3. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
  4. Enteric alpha defensins in norm and pathology
  5. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
  6. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
  7. T cell receptor signaling kinetics takes the stage
  8. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
  9. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
  10. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
  11. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
  12. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
  13. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
  14. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
  15. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response
  16. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes
  17. Target Cell Contributions to Cytotoxic T Cell Sensitivity
  18. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
  19. ICAM-1 co-stimulates target cells to facilitate antigen presentation
  20. Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes
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