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Headache Trials

Please contact (215) 955-2037 to find out the latest information about any of our trials and for information related to enrolling in a trial.

Now Enrolling

IV IBUPROFEN
This is a pilot trial to collect and evaluate information on the use of intravenous ibuprofen (IVIb) in the treatment of an acute migraine attack. Non-Steroidal Anti-inflammatory Drugs (NSAIDS), including ibuprofen, have been shown to be effective in the acute treatment of migraine.  However, the use of oral NSAIDS is sometimes not an option due to the associated symptoms of nausea and vomiting. Thus, IV ibuprofen offers another option. This pilot study will assess the effectiveness and tolerability of injectable ibuprofen for the treatment of migraine in the office setting.

Details: Three visits to the Headache Center

  • Male and female subjects between the ages of 18 and 65
  • Subject experiences between 2-10 migraine attacks per month (during the previous 6 months) with no more than 15 headaches per month
  • Subject is able to come for 4 hour in-clinic treatment of an acute migraine attack
  • Subject is not taking the following medications on a regular basis:  warfarin, lithium, ACE-inhibitors, loop diuretics, thiazide diuretics, ARB's and methotrexate
  • Subject does not have clinically significant anemia, asthma, or allergy to ibuprofen, aspirin (or aspirin related products), NSAIDs, or COX-2 inhibitors

CGRP ANTAGONIST for CHRONIC MIGRAINE
Calcitonin gene-related peptide (CGRP) is a chemical found in various parts of the nervous system known to cause painful inflammation and blood vessel dilation. We are currently conducting two studies using an investigational product to block the binding of CGRP to its receptor. If successful, this would prevent CGRP from causing the inflammation, dilation of blood vessels and expression of proteins known to be associated with CGRP release.

Details: Two or three visits to the Headache Center

  • Males or females aged 18 to 65 years of age
  • History of frequent headaches suggestive of chronic migraine (15 days or more per month) for at least three months prior to screening
  • Subjects have not changed any medications in the past two months
  • No Botox for any reason in the past 6 months
  • No illegal drug use
  • Subjects weigh between 110 and 260 pounds inclusive
  • Subjects are willing to use an acceptable method of birth control for the projected duration of the study

Preventive Headache Studies

Preventive trials are clinical trials that test a medication for its ability to prevent or decrease the frequency, duration, and disability of migraines.

Preventive headache studies are currently being conducted at the Jefferson Headache Center . Men and women ages 18 to 65 who experience frequent migraine headaches may be able to participate in a clinical research study. The study is designed to examine the safety and effectiveness of an investigational drug in the prevention of migraine headaches. Physical and neurologic examinations, as well as study drug, will be provided at no cost to qualified participants. Compensation for travel and related expenses will be provided.

Acute Headache Studies

Acute trials are clinical trials that test a medication for its ability to relieve head pain at the onset of a migraine.

Acute headache studies are currently being conducted at the Jefferson Headache Center . Men and women ages 18 to 65 who experience migraine headaches may be able to participate in a clinical research study. The study is designed to examine the safety and effectiveness of an investigational drug in the relief of eligible migraine attacks. Physical and neurologic examinations, as well as study drug, will be provided at no cost to qualified participants. Compensation for travel and related expenses will be provided.

Cluster Headache Studies

A severe headache that affects predominantly men. Attacks are briefer and more frequent than migraine, are strictly one-sided, and usually occur in clusters that last for weeks. For more information on cluster headache visit the Organization for Understanding Cluster Headaches (O.U.C.H.), a non-profit organization formed to assist cluster headache sufferers and their families.

Cluster headache research is currently being conducted at the Jefferson Headache Center . We have a number of trials open for enrollment at any one time. If you are a cluster headache sufferer of any race and gender between the ages of 18 and 65, either in or out of headache cycle, you may be a candidate for one of our studies. If you are interested learning more about our ongoing research studies please contact us for more information.